[HTML][HTML] Stem cell-based therapy for human diseases

DM Hoang, PT Pham, TQ Bach, ATL Ngo… - Signal transduction and …, 2022 - nature.com
Recent advancements in stem cell technology open a new door for patients suffering from
diseases and disorders that have yet to be treated. Stem cell-based therapy, including …

Tumour stem cells and drug resistance

M Dean, T Fojo, S Bates - Nature Reviews Cancer, 2005 - nature.com
The contribution of tumorigenic stem cells to haematopoietic cancers has been established
for some time, and cells possessing stem-cell properties have been described in several …

Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells

N Niu, I Mercado-Uribe, J Liu - Oncogene, 2017 - nature.com
Our recent perplexing findings that polyploid giant cancer cells (PGCCs) acquired
embryonic-like stemness and were capable of tumor initiation raised two important …

[HTML][HTML] Role of OCT4 in cancer stem-like cells and chemotherapy resistance

IS Mohiuddin, SJ Wei, MH Kang - … Acta (BBA)-Molecular Basis of Disease, 2020 - Elsevier
Cancer stem-like cells (CSCs) contribute to the tumorigenicity, progression, and
chemoresistance of cancers. It is not known whether CSCs arise from normal stem cells or if …

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

Coordination of data collection and analysis … - Nature …, 2007 - nature.com
Abstract The International Stem Cell Initiative characterized 59 human embryonic stem cell
lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques …

Embryonic stem cells: prospects for developmental biology and cell therapy

AM Wobus, KR Boheler - Physiological reviews, 2005 - journals.physiology.org
Stem cells represent natural units of embryonic development and tissue regeneration.
Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity …

Adaptation to culture of human embryonic stem cells and oncogenesis in vivo

DEC Baker, NJ Harrison, E Maltby, K Smith… - Nature …, 2007 - nature.com
The application of human embryonic stem cells (HESCs) to provide differentiated cells for
regenerative medicine will require the continuous maintenance of the undifferentiated stem …

The tumorigenicity of human embryonic stem cells

B Blum, N Benvenisty - Advances in cancer research, 2008 - Elsevier
Human embryonic stem cells (HESCs) are the in vitro descendants of the pluripotent inner
cell mass (ICM) of human blastocyst stage embryos. HESCs can be kept undifferentiated in …

Cancer stem cells: from historical roots to a new perspective

JP Capp - Journal of oncology, 2019 - Wiley Online Library
The relationships between cancer and stemness have a long history that is traced here.
From the mid‐19th century when the first theory on the embryonic origin of cancer was …

Self-renewal of teratocarcinoma and embryonic stem cells

I Chambers, A Smith - Oncogene, 2004 - nature.com
Pluripotent stem cells derived from preimplantation embryos, primordial germ cells or
teratocarcinomas are currently unique in undergoing prolonged symmetrical self-renewal in …