Control of tissue development by morphogens
Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …
tissues to provide spatial information and control properties such as cell fate and tissue …
Morphogen rules: design principles of gradient-mediated embryo patterning
The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …
An activity-specificity trade-off encoded in human transcription factors
Transcription factors (TFs) control specificity and activity of gene transcription, but whether a
relationship between these two features exists is unclear. Here we provide evidence for an …
relationship between these two features exists is unclear. Here we provide evidence for an …
Chromatin accessibility in the Drosophila embryo is determined by transcription factor pioneering and enhancer activation
KJ Brennan, M Weilert, S Krueger, A Pampari, H Liu… - Developmental cell, 2023 - cell.com
Chromatin accessibility is integral to the process by which transcription factors (TFs) read out
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …
Low affinity binding site clusters confer hox specificity and regulatory robustness
In animals, Hox transcription factors define regional identity in distinct anatomical domains.
How Hox genes encode this specificity is a paradox, because different Hox proteins bind …
How Hox genes encode this specificity is a paradox, because different Hox proteins bind …
Suboptimization of developmental enhancers
Transcriptional enhancers direct precise on-off patterns of gene expression during
development. To explore the basis for this precision, we conducted a high-throughput …
development. To explore the basis for this precision, we conducted a high-throughput …
[图书][B] The regulatory genome: gene regulatory networks in development and evolution
EH Davidson - 2010 - books.google.com
Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …
The interaction between biology and evolution has been the subject of great interest in …
Morphogen gradients: from generation to interpretation
Morphogens are long-range signaling molecules that pattern developing tissues in a
concentration-dependent manner. The graded activity of morphogens within tissues …
concentration-dependent manner. The graded activity of morphogens within tissues …
Transcriptional regulatory elements in the human genome
GA Maston, SK Evans, MR Green - Annu. Rev. Genomics Hum …, 2006 - annualreviews.org
The faithful execution of biological processes requires a precise and carefully orchestrated
set of steps that depend on the proper spatial and temporal expression of genes. Here we …
set of steps that depend on the proper spatial and temporal expression of genes. Here we …
Gene regulatory networks for development
M Levine, EH Davidson - Proceedings of the National …, 2005 - National Acad Sciences
The genomic program for development operates primarily by the regulated expression of
genes encoding transcription factors and components of cell signaling pathways. This …
genes encoding transcription factors and components of cell signaling pathways. This …