Hippocampal GABAergic inhibitory interneurons
KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …
of the total neuronal population; however, their remarkable anatomical and physiological …
NMDAR hypofunction animal models of schizophrenia
The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …
Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice
M Jendryka, M Palchaudhuri, D Ursu, B van der Veen… - Scientific reports, 2019 - nature.com
Abstract Muscarinic Designer Receptors Exclusively Activated by Designer Drugs
(DREADD) gated by clozapine-N-oxide (CNO) allow selective G-protein cascade activation …
(DREADD) gated by clozapine-N-oxide (CNO) allow selective G-protein cascade activation …
A selective review of the excitatory-inhibitory imbalance in schizophrenia: underlying biology, genetics, microcircuits, and symptoms
Y Liu, P Ouyang, Y Zheng, L Mi, J Zhao… - Frontiers in cell and …, 2021 - frontiersin.org
Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …
GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia
PJ Harrison, DM Bannerman - Molecular psychiatry, 2023 - nature.com
Involvement of the glutamate system, particularly N-methyl-D-aspartate (NMDA) receptor
hypofunction, has long been postulated to be part of the pathophysiology of schizophrenia …
hypofunction, has long been postulated to be part of the pathophysiology of schizophrenia …
Insulin effects on core neurotransmitter pathways involved in schizophrenia neurobiology: a meta-analysis of preclinical studies. Implications for the treatment
A de Bartolomeis, G De Simone, M De Prisco… - Molecular …, 2023 - nature.com
Impairment of insulin action and metabolic dysregulation have traditionally been associated
with schizophrenia, although the molecular basis of such association remains still elusive …
with schizophrenia, although the molecular basis of such association remains still elusive …
Setd1a insufficiency in mice attenuates excitatory synaptic function and recapitulates schizophrenia-related behavioral abnormalities
SETD1A encodes a histone methyltransferase whose de novo mutations are identified in
schizophrenia (SCZ) patients and confer a large increase in disease risk. Here, we generate …
schizophrenia (SCZ) patients and confer a large increase in disease risk. Here, we generate …
Spatial and temporal boundaries of NMDA receptor hypofunction leading to schizophrenia
K Nakazawa, V Jeevakumar, K Nakao - NPJ schizophrenia, 2017 - nature.com
The N-methyl-d-aspartate receptor hypofunction is one of the most prevalent models of
schizophrenia. For example, healthy subjects treated with uncompetitive N-methyl-d …
schizophrenia. For example, healthy subjects treated with uncompetitive N-methyl-d …
D-serine reconstitutes synaptic and intrinsic inhibitory control of pyramidal neurons in a neurodevelopmental mouse model for schizophrenia
XQ Zhang, L Xu, XY Zhu, ZH Tang, YB Dong… - Nature …, 2023 - nature.com
The hypothesis of N-methyl-D-aspartate receptor (NMDAR) dysfunction for cognitive
impairment in schizophrenia constitutes the theoretical basis for the translational application …
impairment in schizophrenia constitutes the theoretical basis for the translational application …
Glutamatergic dysfunction and synaptic ultrastructural alterations in schizophrenia and autism spectrum disorder: Evidence from human and rodent studies
The correlation between dysfunction in the glutamatergic system and neuropsychiatric
disorders, including schizophrenia and autism spectrum disorder, is undisputed. Both …
disorders, including schizophrenia and autism spectrum disorder, is undisputed. Both …