Molecular and imaging biomarkers in Alzheimer's disease: a focus on recent insights

C Villa, M Lavitrano, E Salvatore, R Combi - Journal of Personalized …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly, affecting millions of people worldwide and clinically characterized by a progressive …

Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders

E Maffioletti, D Tardito, M Gennarelli… - Frontiers in cellular …, 2014 - frontiersin.org
microRNAs (miRNAs) are small non-coding RNAs (20–22 nucleotides) playing a major role
in post-transcriptional regulation of gene expression. miRNAs are predicted to regulate more …

Epigenetic peripheral biomarkers for early diagnosis of Alzheimer's disease

C Villa, A Stoccoro - Genes, 2022 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and represents the
leading cause of cognitive impairment and dementia in older individuals throughout the …

[HTML][HTML] Differentially expressed genes in Alzheimer's disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1

QS Li, L De Muynck - Brain, Behavior, & Immunity-Health, 2021 - Elsevier
Background Alzheimer's disease (AD) is associated with abnormal tau and amyloid-β
accumulation in the brain, leading to neurofibrillary tangles, neuropil threads and …

microRNAs in nociceptive circuits as predictors of future clinical applications

M Kress, A Hüttenhofer, M Landry, R Kuner… - Frontiers in molecular …, 2013 - frontiersin.org
Neuro-immune alterations in the peripheral and central nervous system play a role in the
pathophysiology of chronic pain, and non-coding RNAs (ncRNAs)–and microRNAs …

The potential of microRNAs as biofluid markers of neurodegenerative diseases–a systematic review

PB Danborg, AH Simonsen, G Waldemar… - Biomarkers, 2014 - Taylor & Francis
MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions
of the genome, participating in regulating cellular processes. MiRNAs in biofluids may …

Muscle involvement in amyotrophic lateral sclerosis: understanding the pathogenesis and advancing therapeutics

E Duranti, C Villa - Biomolecules, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal condition characterized by the selective loss of
motor neurons in the motor cortex, brainstem, and spinal cord. Muscle involvement, muscle …

Transcriptome profiling of equine vitamin E deficient neuroaxonal dystrophy identifies upregulation of liver X receptor target genes

CJ Finno, MH Bordbari, SJ Valberg, D Lee… - Free Radical Biology …, 2016 - Elsevier
Specific spontaneous heritable neurodegenerative diseases have been associated with
lower serum and cerebrospinal fluid α-tocopherol (α-TOH) concentrations. Equine …

Influence of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Possible Treatments

E Duranti, C Villa - International Journal of Molecular Sciences, 2023 - mdpi.com
Facioscapulohumeral muscular dystrophy (FSHD) represents the third most common form of
muscular dystrophy and is characterized by muscle weakness and atrophy. FSHD is caused …

Gene expression profiles of M1 and M2 microglia characterized by comparative analysis of public datasets

J Satoh - Clinical and Experimental Neuroimmunology, 2018 - Wiley Online Library
Objective Microglia, immunocompetent cells in the central nervous system, adopt two distinct
activation phenotypes, composed of a pro‐inflammatory and neurotoxic “classical” activation …