[HTML][HTML] Combination therapies with HSP90 inhibitors against colorectal cancer
K Kryeziu, J Bruun, TK Guren, A Sveen… - Biochimica et Biophysica …, 2019 - Elsevier
Oncogene stability and homeostasis mediated by the HSP90 chaperone is a crucial
protection trait of cancer cells. Therefore, HSP90 represents an attractive therapeutic target …
protection trait of cancer cells. Therefore, HSP90 represents an attractive therapeutic target …
HSP90AB1: Helping the good and the bad
M Haase, G Fitze - Gene, 2016 - Elsevier
HSP90AB1 (heat shock protein 90 kDA alpha, class B, member 1), also known as
HSP90beta, is a member of the large family of HSPs which function as molecular …
HSP90beta, is a member of the large family of HSPs which function as molecular …
[HTML][HTML] Prodigiosin/PU-H71 as a novel potential combined therapy for triple negative breast cancer (TNBC): preclinical insights
Prodigiosin, a secondary metabolite red pigment produced by Serratia marcescens, has an
interesting apoptotic efficacy against cancer cell lines with low or no toxicity on normal cells …
interesting apoptotic efficacy against cancer cell lines with low or no toxicity on normal cells …
Synthetic lethal vulnerabilities in KRAS-mutant cancers
AJ Aguirre, WC Hahn - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
KRAS is the most commonly mutated oncogene in human cancer. Most KRAS-mutant
cancers depend on sustained expression and signaling of KRAS, thus making it a high …
cancers depend on sustained expression and signaling of KRAS, thus making it a high …
[HTML][HTML] Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
No effective targeted therapies exist for cancers with somatic KRAS mutations. Here we
develop a synthetic lethal chemical screen in isogenic KRAS-mutant and wild-type cells to …
develop a synthetic lethal chemical screen in isogenic KRAS-mutant and wild-type cells to …
[HTML][HTML] Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells
Colorectal cancers (CRCs) are a critical health issue worldwide. Cancer stem cell (CSC)
lineages are associated with tumour transformation, progression, and malignant …
lineages are associated with tumour transformation, progression, and malignant …
Regulation of mitogen-activated protein kinase signaling pathways by the ubiquitin-proteasome system and its pharmacological potential
S Mathien, C Tesnière, S Meloche - Pharmacological Reviews, 2021 - ASPET
Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved signaling
pathways that play essential roles in transducing extracellular environmental signals into …
pathways that play essential roles in transducing extracellular environmental signals into …
Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells
TY Lin, WJ Hua, H Yeh, AJ Tseng - Phytomedicine, 2021 - Elsevier
Abstract Background Ling Zhi-8 (LZ-8) and GMI are two fungal immunomodulatory proteins
(FIPs) with a similar structure and amino acid sequence and are respectively obtained from …
(FIPs) with a similar structure and amino acid sequence and are respectively obtained from …
[HTML][HTML] TRPC3 regulates the proliferation and apoptosis resistance of triple negative breast cancer cells through the TRPC3/RASA4/MAPK pathway
Y Wang, YX Qi, Z Qi, SY Tsang - Cancers, 2019 - mdpi.com
Currently, there is no effective molecular-based therapy for triple-negative breast cancer
(TNBC). Canonical transient receptor potential isoform 3 (TRPC3) was previously shown to …
(TNBC). Canonical transient receptor potential isoform 3 (TRPC3) was previously shown to …
HSP90 inhibitors for cancer therapy and overcoming drug resistance
Since the initial discovery of heat shock protein 90 (HSP90) as a target for anticancer
therapy, tremendous progress has been made in developing a multitude of potent first-and …
therapy, tremendous progress has been made in developing a multitude of potent first-and …