Pathophysiological mechanisms and clinical associations of non-alcoholic fatty pancreas disease

A Pagkali, A Makris, K Brofidi, AP Agouridis… - Diabetes, Metabolic …, 2024 - Taylor & Francis
Abstract Non-Alcoholic Fatty Pancreas disease (NAFPD), characterized by fat accumulation
in pancreatic tissue, is an emerging clinical entity. However, the clinical associations, the …

Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni

J Wang, C Paz, G Padalino, A Coghlan, Z Lu… - Science, 2020 - science.org
Schistosome parasites kill 250,000 people every year. Treatment of schistosomiasis relies
on the drug praziquantel. Unfortunately, a scarcity of molecular tools has hindered the …

Dendrobium huoshanense polysaccharide regulates hepatic glucose homeostasis and pancreatic β-cell function in type 2 diabetic mice

HY Wang, QM Li, NJ Yu, WD Chen, XQ Zha… - Carbohydrate …, 2019 - Elsevier
In the present study, the hypoglycemic mechanism of a homogeneous Dendrobium
huoshanense polysaccharide (GXG) was investigated using type 2 diabetic (T2D) mouse …

MST kinases and metabolism

CM Pombo, C Iglesias, M Sartages, JB Zalvide - Endocrinology, 2019 - academic.oup.com
Since the discovery of the mammalian sterile twenty (MST) kinase family of proteins
(MST1/STK4, MST2/STK3, MST3/STK24, and SOK1/STK25), much has been done that adds …

Silencing of FABP 1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease

T Mukai, M Egawa, T Takeuchi, H Yamashita… - FEBS open …, 2017 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence worldwide and has
been identified as a risk factor for cirrhosis and hepatocellular carcinoma. However, there is …

A polysaccharide NAP-3 from Naematelia aurantialba: Structural characterization and adjunctive hypoglycemic activity

L Sun, J Jiang, T Jing, D Hu, J Zhu, Y Zeng, Y Pang… - Carbohydrate …, 2023 - Elsevier
Abstract A novel polysaccharide (NAP-3) was isolated and purified from Naematelia
aurantialba after water extraction. The structure of NAP-3, which was determined by FT-IR …

Novel strategy for oral peptide delivery in incretin-based diabetes treatment

Y Xu, M Van Hul, F Suriano, V Préat, PD Cani… - Gut, 2020 - gut.bmj.com
Objective To fulfil an unmet therapeutic need for treating type 2 diabetes by developing an
innovative oral drug delivery nanosystem increasing the production of glucagon-like peptide …

[HTML][HTML] Physicochemical characterization and hypoglycemic potential of a novel polysaccharide from Polygonatum sibiricum Red through PI3K/Akt mediated …

SZ Xie, WJ Zhang, W Liu, JB Bai, SL Xie… - Journal of Functional …, 2022 - Elsevier
The rhizome of Polygonatum sibiricum is traditionally used as a tonic-type edible herb. In
this study, a homogenous polysaccharide (PSPW) was isolated from P. sibiricum. PSPW …

[HTML][HTML] Targeted nanoparticles towards increased L cell stimulation as a strategy to improve oral peptide delivery in incretin-based diabetes treatment

Y Xu, H De Keersmaecker, K Braeckmans, S De Smedt… - Biomaterials, 2020 - Elsevier
The delivery of therapeutic peptides via the oral route remains one of biggest challenges in
the pharmaceutical industry. Recently, we have described an alternative improved drug …

[HTML][HTML] Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring

Y Xia, E Andersson, SK Anand, E Cansby… - Hepatology …, 2023 - journals.lww.com
Background: NAFLD has become the leading cause of chronic liver disease worldwide
afflicting about one quarter of the adult population. NASH is a severe subtype of NAFLD …