The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …

The bottom-up assembly of biological and chemical components opens exciting
opportunities to engineer artificial vesicular systems for applications with previously unmet …

Ligands bound to protein assemblies provide critical information for function, yet are often
difficult to capture and define. Here we develop a top-down method,'nativeomics', unifying …

Detergents enable the investigation of membrane proteins by mass spectrometry. Detergent
designers aim to improve underlying methodologies and are confronted with the challenge …

Voltage-sensing domains control the activation of voltage-gated ion channels, with a few
exceptions. One such exception is the sperm-specific Na+/H+ exchanger SLC9C1, which is …

Glucose transporters (GLUTs) are essential for organism-wide glucose homeostasis in
mammals, and their dysfunction is associated with numerous diseases, such as diabetes …

Abstract The Na+/H+ exchanger SLC9B2, also known as NHA2, correlates with the long-
sought-after Na+/Li+ exchanger linked to the pathogenesis of diabetes mellitus and …

Protein stability in detergent or membrane-like environments is the bottleneck for structural
studies on integral membrane proteins (IMP). Irrespective of the method to study the …

Membrane protein purification by means of detergents is key to isolating membrane‐bound
therapeutic targets. The role of the detergent structure in this process, however, is not well …

Abstract Na+/H+ exchangers (NHEs) are ancient membrane‐bound nanomachines that
work to regulate intracellular pH, sodium levels and cell volume. NHE activities contribute to …