Phosphorylated tau in Alzheimer's disease and other tauopathies
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
Neuroinflammation as a common feature of neurodegenerative disorders
L Guzman-Martinez, RB Maccioni, V Andrade… - Frontiers in …, 2019 - frontiersin.org
Neurodegenerative diseases share the fact that they derive from altered proteins that
undergo an unfolding process followed by formation of β-structures and a pathological …
undergo an unfolding process followed by formation of β-structures and a pathological …
Structure-based classification of tauopathies
The ordered assembly of tau protein into filaments characterizes several neurodegenerative
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …
The second NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with
exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB …
exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB …
Pathology of neurodegenerative diseases
BN Dugger, DW Dickson - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Neurodegenerative disorders are characterized by progressive loss of selectively vulnerable
populations of neurons, which contrasts with select static neuronal loss because of …
populations of neurons, which contrasts with select static neuronal loss because of …
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the
abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other …
abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other …
Mechanisms of secretion and spreading of pathological tau protein
CA Brunello, M Merezhko, RL Uronen… - Cellular and Molecular …, 2020 - Springer
Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …
An autoradiographic evaluation of AV-1451 Tau PET in dementia
VJ Lowe, G Curran, P Fang, AM Liesinger… - Acta neuropathologica …, 2016 - Springer
Background It is essential to determine the specificity of AV-1451 PET for tau in brain
imaging by using pathological comparisons. We performed autoradiography in autopsy …
imaging by using pathological comparisons. We performed autoradiography in autopsy …
Invited review: neuropathology of tauopathies: principles and practice
GG Kovacs - Neuropathology and applied neurobiology, 2015 - Wiley Online Library
Tauopathies are clinically, morphologically and biochemically heterogeneous
neurodegenerative diseases characterized by the deposition of abnormal tau protein in the …
neurodegenerative diseases characterized by the deposition of abnormal tau protein in the …
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous
human neurodegenerative diseases, including Alzheimer's disease, tangle-only dementia …
human neurodegenerative diseases, including Alzheimer's disease, tangle-only dementia …