A Humanized Yeast System for Evaluating the Protein Prenylation of a Wide Range of Human and Viral CaaX Sequences

ER Hildebrandt, A Sarkar, R Ravishankar, JH Kim… - …, 2023 - pmc.ncbi.nlm.nih.gov
The C-terminal CaaX sequence (cysteine-aliphatic-aliphatic-any of several amino acids) is
subject to isoprenylation on the conserved cysteine and is estimated to occur in 1–2% of …

Evaluating protein prenylation of human and viral CaaX sequences using a humanized yeast system

ER Hildebrandt, A Sarkar… - Disease Models & …, 2024 - journals.biologists.com
Prenylated proteins are prevalent in eukaryotic biology (∼ 1-2% of proteins) and are
associated with human disease, including cancer, premature aging and infections …