The microbiome in inflammatory bowel disease: current status and the future ahead

AD Kostic, RJ Xavier, D Gevers - Gastroenterology, 2014 - Elsevier
Studies of the roles of microbial communities in the development of inflammatory bowel
disease (IBD) have reached an important milestone. A decade of genome-wide association …

[HTML][HTML] Inflammatory bowel disease: pathogenesis

YZ Zhang, YY Li - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is
characterized by chronic relapsing intestinal inflammation. It has been a worldwide health …

[HTML][HTML] The role of neutrophils during intestinal inflammation

BM Fournier, CA Parkos - Mucosal immunology, 2012 - Elsevier
Polymorphonuclear leukocytes or neutrophils play a critical role in the maintenance of
intestinal homeostasis. They have elegant defense mechanisms to eliminate microbes that …

[HTML][HTML] Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?

GL Hold, M Smith, C Grange, ER Watt… - World journal of …, 2014 - ncbi.nlm.nih.gov
Our understanding of the microbial involvement in inflammatory bowel disease (IBD)
pathogenesis has increased exponentially over the past decade. The development of newer …

Microbial influences in inflammatory bowel diseases

RB Sartor - Gastroenterology, 2008 - Elsevier
The predominantly anaerobic microbiota of the distal ileum and colon contain an
extraordinarily complex variety of metabolically active bacteria and fungi that intimately …

Partial enteral nutrition with a Crohn's disease exclusion diet is effective for induction of remission in children and young adults with Crohn's disease

R Sigall-Boneh, T Pfeffer-Gik, I Segal… - Inflammatory bowel …, 2014 - academic.oup.com
Background Exclusive enteral nutrition is effective for inducing remission in active pediatric
Crohn's disease. Partial enteral nutrition (PEN) with free diet is ineffective for inducing …

Dysbiotic events in gut microbiota: impact on human health

S Schippa, MP Conte - Nutrients, 2014 - mdpi.com
The human body is colonized by a large number of microbes coexisting peacefully with their
host. The most colonized site is the gastrointestinal tract (GIT). More than 70% of all the …

Intestinal barrier dysfunction in inflammatory bowel diseases

MA McGuckin, R Eri, LA Simms… - Inflammatory bowel …, 2009 - academic.oup.com
The etiology of human inflammatory bowel diseases (IBDs) is believed to involve
inappropriate host responses to the complex commensal microbial flora in the gut, although …

Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in …

M Baumgart, B Dogan, M Rishniw, G Weitzman… - The ISME …, 2007 - academic.oup.com
Intestinal bacteria are implicated increasingly as a pivotal factor in the development of
Crohn's disease, but the specific components of the complex polymicrobial enteric …

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

AM Smith, FZ Rahman, BH Hayee, SJ Graham… - Journal of Experimental …, 2009 - rupress.org
The cause of Crohn's disease (CD) remains poorly understood. Counterintuitively, these
patients possess an impaired acute inflammatory response, which could result in delayed …