Per occasion, alcohol consumption is higher in adolescents than in adults in both humans
and laboratory animals, with changes in the adolescent brain probably contributing to this …

Substance use disorders occur commonly in patients with schizophrenia and dramatically
worsen their overall clinical course. While the exact mechanisms contributing to substance …

The prefrontal cortex (PFC) is a brain region that is critically involved in cognitive function
and inhibitory control of behavior, and adolescence represents an important period of …

Adolescence is the transitional period between childhood and adulthood, during which
extensive brain development occurs. Since this period also overlaps with the initiation of …

One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

Adolescence is a period of significant neurobiological change that occurs as individuals
transition from childhood to adulthood. Because the nervous system is in a relatively labile …

Background Adolescent alcohol use is a major public health concern and is strongly
correlated with the development of alcohol abuse problems in adulthood. Adolescence is …

Alcohol is the most commonly abused substance among adolescents, promoting the
development of substance use disorders and compromised decision-making in adulthood …

Adolescent alcohol use remains a major public health concern due in part to well-
established findings implicating the age of onset in alcohol use in the development of …

Delayed maturation of the adolescent prefrontal cortex may render it particularly vulnerable
to insults, including those associated with drugs of abuse. Using a rat model of binge alcohol …