Towards a deeper understanding of the vaginal microbiota

M France, M Alizadeh, S Brown, B Ma, J Ravel - Nature microbiology, 2022 - nature.com
The human vaginal microbiota is a critical determinant of vaginal health. These communities
live in close association with the vaginal epithelium and rely on host tissues for resources …

The microbiome and gynaecological cancer development, prevention and therapy

P Łaniewski, ZE Ilhan, MM Herbst-Kralovetz - Nature Reviews Urology, 2020 - nature.com
The female reproductive tract (FRT), similar to other mucosal sites, harbours a site-specific
microbiome, which has an essential role in maintaining health and homeostasis. In the …

Roles of the microbiota of the female reproductive tract in gynecological and reproductive health

B Zhu, Z Tao, L Edupuganti, MG Serrano… - … and Molecular Biology …, 2022 - Am Soc Microbiol
The microbiome of the female reproductive tract defies the convention that high biodiversity
is a hallmark of an optimal ecosystem. Although not universally true, a homogeneous …

Gram‐positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract

KA Kline, AL Lewis - Urinary tract infections: molecular …, 2017 - Wiley Online Library
Uncomplicated urinary‐tract infection (UTI) is most common in young, sexually active,
nonpregnant, premenopausal women. Gram‐negative bacteria are isolated from 75% to …

[HTML][HTML] Bacterial vaginosis and health-associated bacteria modulate the immunometabolic landscape in 3D model of human cervix

P Łaniewski, MM Herbst-Kralovetz - npj Biofilms and Microbiomes, 2021 - nature.com
Bacterial vaginosis (BV) is an enigmatic polymicrobial condition characterized by a
depletion of health-associated Lactobacillus and an overgrowth of anaerobes. Importantly …

[HTML][HTML] The cervicovaginal mucus barrier

G Lacroix, V Gouyer, F Gottrand… - International Journal of …, 2020 - mdpi.com
Preterm births are a global health priority that affects 15 million babies every year worldwide.
There are no effective prognostic and therapeutic strategies relating to preterm delivery, but …

Influence of Biofilm Formation by Gardnerella vaginalis and Other Anaerobes on Bacterial Vaginosis

A Machado, N Cerca - The Journal of infectious diseases, 2015 - academic.oup.com
Bacterial vaginosis (BV) is the worldwide leading vaginal disorder among women of
reproductive age. BV is characterized by the replacement of beneficial lactobacilli and the …

[HTML][HTML] The composition of human vaginal microbiota transferred at birth affects offspring health in a mouse model

E Jašarević, EM Hill, PJ Kane, L Rutt, T Gyles… - Nature …, 2021 - nature.com
Newborns are colonized by maternal microbiota that is essential for offspring health and
development. The composition of these pioneer communities exhibits individual differences …

[HTML][HTML] Gardnerella vaginalis as a Cause of Bacterial Vaginosis: Appraisal of the Evidence From in vivo Models

S Morrill, NM Gilbert, AL Lewis - Frontiers in cellular and infection …, 2020 - frontiersin.org
Koch's postulates dictate the use of experimental models to illustrate features of human
disease and provide evidence for a singular organism as the cause. The underlying cause …

The cervicovaginal microbiota-host interaction modulates Chlamydia trachomatis infection

VL Edwards, SB Smith, EJ McComb, J Tamarelle, B Ma… - MBio, 2019 - Am Soc Microbiol
The mechanism (s) by which Lactobacillus-dominated cervicovaginal microbiota provide a
barrier to Chlamydia trachomatis infection remain (s) unknown. Here we evaluate the impact …