The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications
Developments in high-throughput microbial genomic sequencing and other systems biology
techniques have given novel insight into the potential contribution of the gut microbiota to …
techniques have given novel insight into the potential contribution of the gut microbiota to …
The promise of the gut microbiome as part of individualized treatment strategies
DA Schupack, RAT Mars, DH Voelker… - Nature reviews …, 2022 - nature.com
Variability in disease presentation, progression and treatment response has been a central
challenge in medicine. Although variability in host factors and genetics are important, it has …
challenge in medicine. Although variability in host factors and genetics are important, it has …
Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization
FC Pereira, K Wasmund, I Cobankovic… - Nature …, 2020 - nature.com
Many intestinal pathogens, including Clostridioides difficile, use mucus-derived sugars as
crucial nutrients in the gut. Commensals that compete with pathogens for such nutrients are …
crucial nutrients in the gut. Commensals that compete with pathogens for such nutrients are …
Establishing or exaggerating causality for the gut microbiome: lessons from human microbiota-associated rodents
Human diseases are increasingly linked with an altered or" dysbiotic" gut microbiota, but
whether such changes are causal, consequential, or bystanders to disease is, for the most …
whether such changes are causal, consequential, or bystanders to disease is, for the most …
Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent …
Q Li, Y Cui, B Xu, Y Wang, F Lv, Z Li, H Li… - Pharmacological …, 2021 - Elsevier
As an effective drug against acute enteritis diarrhea, Gegen Qinlian decoction (GQD) has a
history of 2000 years. However, the potential molecular mechanism through which GQD …
history of 2000 years. However, the potential molecular mechanism through which GQD …
Mining the microbiota for microbial and metabolite-based immunotherapies
Trillions of microorganisms transit through and reside in the mammalian gastrointestinal tract
each day, collectively producing thousands of small molecules and metabolites with local …
each day, collectively producing thousands of small molecules and metabolites with local …
Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
JR Fletcher, CM Pike, RJ Parsons, AJ Rivera… - Nature …, 2021 - nature.com
Clostridioides difficile is a bacterial pathogen that causes a range of clinical disease from
mild to moderate diarrhea, pseudomembranous colitis, and toxic megacolon. Typically, C …
mild to moderate diarrhea, pseudomembranous colitis, and toxic megacolon. Typically, C …
Longitudinal evaluation of fecal microbiota transplantation for ameliorating calf diarrhea and improving growth performance
Calf diarrhea is associated with enteric infections, and also provokes the overuse of
antibiotics. Therefore, proper treatment of diarrhea represents a therapeutic challenge in …
antibiotics. Therefore, proper treatment of diarrhea represents a therapeutic challenge in …
Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota
The involvement of host immunity in the gut microbiota-mediated colonization resistance to
Clostridioides difficile infection (CDI) is incompletely understood. Here, we show that …
Clostridioides difficile infection (CDI) is incompletely understood. Here, we show that …
Bile acid-independent protection against Clostridioides difficile infection
Clostridioides difficile infections occur upon ecological/metabolic disruptions to the normal
colonic microbiota, commonly due to broad-spectrum antibiotic use. Metabolism of bile acids …
colonic microbiota, commonly due to broad-spectrum antibiotic use. Metabolism of bile acids …