Microglia emerge as central players in brain disease
MW Salter, B Stevens - Nature medicine, 2017 - nature.com
There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …
Microglia and neurodevelopmental disorders
Mounting evidence indicates that microglia, which are the resident immune cells of the brain,
play critical roles in a diverse array of neurodevelopmental processes required for proper …
play critical roles in a diverse array of neurodevelopmental processes required for proper …
Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …
Microglia function in the central nervous system during health and neurodegeneration
M Colonna, O Butovsky - Annual review of immunology, 2017 - annualreviews.org
Microglia are resident cells of the brain that regulate brain development, maintenance of
neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct …
neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct …
Microglia and beyond: innate immune cells as regulators of brain development and behavioral function
KM Lenz, LH Nelson - Frontiers in immunology, 2018 - frontiersin.org
Innate immune cells play a well-documented role in the etiology and disease course of
many brain-based conditions, including multiple sclerosis, Alzheimer's disease, traumatic …
many brain-based conditions, including multiple sclerosis, Alzheimer's disease, traumatic …
Microglia in physiology and disease
SA Wolf, H Boddeke… - Annual review of …, 2017 - annualreviews.org
As the immune-competent cells of the brain, microglia play an increasingly important role in
maintaining normal brain function. They invade the brain early in development, transform …
maintaining normal brain function. They invade the brain early in development, transform …
Advancing the understanding of autism disease mechanisms through genetics
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …
fueled remarkable advances in our understanding of its potential neurobiological …
Microglia contact induces synapse formation in developing somatosensory cortex
A Miyamoto, H Wake, AW Ishikawa, K Eto… - Nature …, 2016 - nature.com
Microglia are the immune cells of the central nervous system that play important roles in
brain pathologies. Microglia also help shape neuronal circuits during development, via …
brain pathologies. Microglia also help shape neuronal circuits during development, via …
Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders
SB Nelson, V Valakh - Neuron, 2015 - cell.com
Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition …
mutations in many genes affecting the ratio between neuronal excitation and inhibition …