Haptoglobin: From hemoglobin scavenging to human health

A di Masi, G De Simone, C Ciaccio, S D'Orso… - Molecular Aspects of …, 2020 - Elsevier
Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …

Unique contribution of haptoglobin and haptoglobin genotype in aneurysmal subarachnoid hemorrhage

SL Blackburn, PT Kumar, D McBride… - Frontiers in …, 2018 - frontiersin.org
Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological
deficits. Much of this is related to the effects of blood in the subarachnoid space which …

Albiflorin attenuates high glucose-induced endothelial apoptosis via suppressing PARP1/NF-κB signaling pathway

R Yang, Y Yang - Inflammation Research, 2023 - Springer
Abstract Objective Paeonia lactiflora Pall has long been recognized as an anti-inflammatory
traditional Chinese herbal medicine. We aimed to study the pharmacological action of …

Scutellarin exerts protective effects against atherosclerosis in rats by regulating the Hippo–FOXO3A and PI3K/AKT signaling pathways

Y Fu, S Sun, H Sun, J Peng, X Ma, L Bao… - Journal of Cellular …, 2019 - Wiley Online Library
Atherosclerosis (AS), a progressive disorder, is one of the tough challenges in the clinic.
Scutellarin, an extract from Herba Erigerontis, is found to have oxygen‐free radicals …

RPS4Y1 promotes high glucose-induced endothelial cell apoptosis and inflammation by activation of the p38 MAPK signaling

Y Chen, Y Chen, C Tang, Q Zhao, T Xu… - Diabetes, Metabolic …, 2021 - Taylor & Francis
Aim Endothelial dysfunction is a key pathological basis for diabetes mellitus complications,
including diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. This …

Impact of Vitamin E supplementation on vascular function in haptoglobin genotype stratified diabetes patients (EVAS Trial): a randomised controlled trial

R Dalan, LL Goh, CJ Lim, A Seneviratna, H Liew… - Nutrition & …, 2020 - nature.com
Abstract Aims Vitamin E (Vit-E) may preferentially improve cardiovascular risk in haptoglobin
2-2 (Hp2-2) genotype diabetes individuals. We studied the impact of Vit-E supplementation …

MicroRNA-106 attenuates hyperglycemia-induced vascular endothelial cell dysfunction by targeting HMGB1

R Liu, Q Luo, W You, M Jin - Gene, 2018 - Elsevier
Chronic wounds are a common surgical problem exacerbated by diabetes. A hyperglycemic
microenvironment induces inflammation and apoptosis, and plays an important role in …

The preventative effects of Lactococcus Lactis metabolites against LPS-induced sepsis

Y Fu, S Zhang, Q Yue, Z An, M Zhao, C Zhao… - Frontiers in …, 2024 - frontiersin.org
Introduction Sepsis is a syndrome of organ dysfunction caused by a dysregulated host
response to infection and septic shock. Currently, antibiotic therapy is the standard treatment …

Modulatory action of withaferin‐A on oxidative damage through regulation of inflammatory mediators and apoptosis via PI3K/AKT signaling pathway in high …

L Zhang, Y Shi, M Yan, G Zhang - Journal of Biochemical and …, 2022 - Wiley Online Library
Statins are widely used lipid‐lowering drugs that cause many side effects. Withaferin‐A
(WA), popularly known as Ashwagandha, an ancient Indian medicinal herb, is extracted from …

[PDF][PDF] Effect of L-carnitine and conjugated linoleic acid supplements on haemoglobin levels and haptoglobin genotype in chronic kidney disease

نعمتی, علی پناه مقدم, مأذنی, محمد, درویشی… - Journal of the Pakistan …, 2019‎ - core.ac.uk
Objective: To investigate the efficacy of L-carnitine (LC) and conjugated linoleic acid (CLA)
supplements on haemoglobin levels and inflammatory markers in chronic kidney disease …