Rare diseases affect 30 million people in the USA and more than 300–400 million
worldwide, often causing chronic illness, disability, and premature death. Traditional …

Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

Summary Coronavirus disease 2019 (COVID-19) is a pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is defined by respiratory …

Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

The immature physiology of cardiomyocytes derived from human induced pluripotent stem
cells (hiPSCs) limits their utility for drug screening and disease modelling. Here we show …

The functions of the heart are achieved through coordination of different cardiac cell
subtypes (eg, ventricular, atrial, conduction-tissue cardiomyocytes). Human pluripotent stem …

The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …