Zinc transporters and their functional integration in mammalian cells
Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …
The function and regulation of zinc in the brain
RF Krall, T Tzounopoulos, E Aizenman - Neuroscience, 2021 - Elsevier
Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …
Structural mechanism of intracellular autoregulation of zinc uptake in ZIP transporters
Zinc is an essential micronutrient that supports all living organisms through regulating
numerous biological processes. However, the mechanism of uptake regulation by …
numerous biological processes. However, the mechanism of uptake regulation by …
Toward unzipping the ZIP metal transporters: structure, evolution, and implications on drug discovery against cancer
J Hu - The FEBS journal, 2021 - Wiley Online Library
The Zrt‐/Irt‐like protein (ZIP) family consists of divalent metal transporters, ubiquitous in all
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …
Function, structure, and transport aspects of ZIP and ZnT zinc transporters in immune cells
Zinc is an important trace metal in immune systems, and zinc transporters are involved in
many immune responses. Recent advances have revealed the structural and biochemical …
many immune responses. Recent advances have revealed the structural and biochemical …
[HTML][HTML] Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP
H Fujishiro, T Kambe - Journal of Pharmacological Sciences, 2022 - Elsevier
Manganese (Mn) is an essential trace element required for various biological processes.
However, excess Mn causes serious side effects in humans, including parkinsonism. Thus …
However, excess Mn causes serious side effects in humans, including parkinsonism. Thus …
Zinc as a countermeasure for cadmium toxicity
H Yu, J Zhen, J Leng, L Cai, H Ji… - Acta Pharmacologica …, 2021 - nature.com
Cadmium (Cd) is an important environmental pollutant and long-term Cd exposure is closely
related to autoimmune diseases, cancer, cardiovascular diseases (CVD), and hepatic …
related to autoimmune diseases, cancer, cardiovascular diseases (CVD), and hepatic …
Zinc homeostasis and regulation: Zinc transmembrane transport through transporters
S Yin, M Duan, B Fang, G Zhao, X Leng… - Critical Reviews in …, 2023 - Taylor & Francis
The second abundant micronutrient, zinc, is attracting more and more attention for it
performs essential functions in living organisms and bears close relationships with the …
performs essential functions in living organisms and bears close relationships with the …
Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter
Abstract The Zrt-/Irt-like protein (ZIP) family consists of ubiquitously expressed divalent metal
transporters critically involved in maintaining systemic and cellular homeostasis of zinc, iron …
transporters critically involved in maintaining systemic and cellular homeostasis of zinc, iron …
[HTML][HTML] From zinc homeostasis to disease progression: Unveiling the neurodegenerative puzzle
YG Fan, TY Wu, LX Zhao, RJ Jia, H Ren, WJ Hou… - Pharmacological …, 2023 - Elsevier
Zinc is a crucial trace element in the human body, playing a role in various physiological
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …