Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

Zinc is an essential micronutrient that supports all living organisms through regulating
numerous biological processes. However, the mechanism of uptake regulation by …

The Zrt‐/Irt‐like protein (ZIP) family consists of divalent metal transporters, ubiquitous in all
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …

Zinc is an important trace metal in immune systems, and zinc transporters are involved in
many immune responses. Recent advances have revealed the structural and biochemical …

Manganese (Mn) is an essential trace element required for various biological processes.
However, excess Mn causes serious side effects in humans, including parkinsonism. Thus …

Cadmium (Cd) is an important environmental pollutant and long-term Cd exposure is closely
related to autoimmune diseases, cancer, cardiovascular diseases (CVD), and hepatic …

The second abundant micronutrient, zinc, is attracting more and more attention for it
performs essential functions in living organisms and bears close relationships with the …

Abstract The Zrt-/Irt-like protein (ZIP) family consists of ubiquitously expressed divalent metal
transporters critically involved in maintaining systemic and cellular homeostasis of zinc, iron …

Zinc is a crucial trace element in the human body, playing a role in various physiological
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …