The association between CFTR gene mutation heterozygosity and asthma development: A systematic review

D Koumpagioti, D Moriki, B Boutopoulou… - Journal of clinical …, 2023 - mdpi.com
Asthma is caused by complex interactions between environmental and genetic factors.
Various genes have been implicated as potential risk factors in the development of asthma; …

[HTML][HTML] Long-term alterations in lung epithelial cells after EL-RSV infection exacerbate allergic responses through IL-1β-induced pathways

SB Morris, R Ocadiz-Ruiz, N Asai, CA Malinczak… - Mucosal …, 2024 - Elsevier
Early-life (EL) respiratory infections increase pulmonary disease risk, especially EL-
Respiratory Syncytial Virus (EL-RSV) infections linked to asthma. Mechanisms underlying …

CFTR complex alleles and phenotypic variability in cystic fibrosis disease

A El-Seedy, V Ladeveze - Cellular and Molecular Biology, 2024 - mail.cellmolbiol.org
Cystic fibrosis (CF) is inherited by CFTR (cystic fibrosis transmembrane conductance
regulator) gene mutations. A variety of mutations have been identified in the CFTR gene that …

PM2. 5 Exposure Inhibits Transepithelial Anion Short-circuit Current by Downregulating P2Y2 Receptor/CFTR Pathway

X Liu, Z Li, J Shan, F Wang, Z Li… - International Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Fine particulate matter (PM2. 5) can damage airway epithelial barriers. The anion transport
system plays a crucial role in airway epithelial barriers. However, the detrimental effect and …