Pharmacogenetics represents an exciting, new promising tool for the individualisation of
therapy. Several genetic polymorphisms and haplotypes have been considered in an …

To evaluate the contribution of candidate gene association studies to the understanding of
genetic susceptibility to childhood acute lymphoblastic leukemia we conducted a systematic …

Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer, accounting for
nearly 30% of all paediatric cancers and 80% of childhood leukaemias. Polymorphisms in …

Methlenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate
metabolism. This enzyme is mapped on chromosome 1, which is located at the end of the …

Abstract Background Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C
polymorphisms have been implicated in childhood acute lymphoblastic leukemia (ALL) risk …

Abstract Background 5, 10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T
and A1298C, have been reported to be associated with decreased risk of acute …

Objective The methylenetetrahydrofolate reductase gene C677T polymorphism is closely
related to the acute lymphoblastic leukemia. Several case–control studies have investigated …

Objective: High-dose methotrexate (HD-MTX) is widely used in the consolidation phase of
childhood acute lymphoblastic leukemia (ALL), but the roles that polymorphisms in folate …

Background: Acute lymphoblastic leukemia (ALL) is a complex disease caused by
interactions between hazardous exogenous or/and endogenous agents and many mild …

The aetiology of leukaemias among children is believed to be distinct from that of adults,
mainly due to the clearer role for early life exposures, including those in utero. However, few …