Innate immune gene polymorphisms in tuberculosis

AK Azad, W Sadee, LS Schlesinger - Infection and immunity, 2012 - Am Soc Microbiol
Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …

Influence of genetic polymorphism towards pulmonary tuberculosis susceptibility

M Harishankar, P Selvaraj, R Bethunaickan - Frontiers in medicine, 2018 - frontiersin.org
Tuberculosis (TB) is still remains the major threat for human health worldwide. Several case-
control, candidate-gene, family studies and genome-wide association studies (GWAS) …

Genetic susceptibility in tuberculosis

JJ YIM, P Selvaraj - Respirology, 2010 - Wiley Online Library
The importance of host genetic factors in determining susceptibility to tuberculosis (TB) has
been studied extensively using various methods, such as case‐control, candidate gene and …

[PDF][PDF] Генетические основы коморбидности у человека

ВП Пузырев - 2015 - vital.lib.tsu.ru
В обзоре рассмотрена динамика представлений о феномене сочетания болезней
(коморбидности) у человека. Представлен анализ генетических основ трех форм …

Increased interleukin-10 and interferon-γ levels in Plasmodium vivax malaria suggest a reciprocal regulation which is not altered by IL-10 gene promoter …

TS Medina, SPT Costa, MD Oliveira, AM Ventura… - Malaria journal, 2011 - Springer
Background In human malaria, the naturally-acquired immune response can result in either
the elimination of the parasite or a persistent response mediated by cytokines that leads to …

IFNG+ 874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of …

ACR Vallinoto, ES Graça, MS Araújo, VN Azevedo… - Human immunology, 2010 - Elsevier
Regarding the importance of interferon-γ (IFN-γ) in protective immunity against
Mycobacterium tuberculosis and the functional role of IFNG+ 874T/A single nucleotide …

A functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis

G Zhang, B Zhou, W Wang, M Zhang… - The Journal of …, 2012 - academic.oup.com
Background Genetic variation influences susceptibility or resistance to tuberculosis.
Interleukin 6 (IL-6) contributes to protection against tuberculosis in mice. However, its role in …

The research progress of host genes and tuberculosis susceptibility

L Cai, Z Li, X Guan, K Cai, L Wang… - … medicine and cellular …, 2019 - Wiley Online Library
Background/Aims. Nucleotide diversity may affect the immune regulation of tuberculosis (TB)
patients, leading to the individual susceptibility to TB. In recent years, there are a lot of …

Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis

NLS Tang, HPY Fan, KC Chang, JKL Ching… - Clinica chimica acta, 2009 - Elsevier
BACKGROUND: Previous studies showed that activation of CXCL-10 and other chemokines
were prominent in many infectious diseases. These chemokines are components of innate …

Toll-like receptors, tumor necrosis factor–α, and interleukin-10 gene polymorphisms in risk of pulmonary tuberculosis and disease severity

M Ma, L Xie, S Wu, F Tang, H Li, Z Zhang, H Yang… - Human Immunology, 2010 - Elsevier
Toll-like receptors (TLRs) and cytokines play key roles in innate and adaptive immunity
against Mycobacterium tuberculosis (M. TB). The aim of this study was to investigate …