Recognition in the domain of molecular chirality: from noncovalent interactions to separation of enantiomers

P Peluso, B Chankvetadze - Chemical Reviews, 2022 - ACS Publications
It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in
nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules …

Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges

L Ferrazzano, M Catani, A Cavazzini, G Martelli… - Green …, 2022 - pubs.rsc.org
Developing greener synthesis processes is an inescapable necessity to transform the
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …

Recent trends in chiral supercritical fluid chromatography

C West - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
This paper presents a review of the recent literature covering separations of enantiomers
achieved with supercritical fluid chromatography (SFC) or subcritical fluid chromatography …

A look at the importance of chirality in drug activity: Some significative examples

J Ceramella, D Iacopetta, A Franchini, M De Luca… - Applied Sciences, 2022 - mdpi.com
Chirality plays an important role in the development of many pharmaceuticals, being a
general property of 'handedness'; nevertheless, a large number of pharmaceuticals are still …

Some thoughts about enantioseparations in capillary electrophoresis

S Fanali, B Chankvetadze - Electrophoresis, 2019 - Wiley Online Library
In this overview the goal of the authors was to analyze from the historical perspective the
reasons of success and failure of chiral capillary electrophoresis. In addition, the current …

Recent advances in microextraction techniques using sustainable green solvents for mass spectrometry analysis

Y Zhang, M Chen, L Li, Y Lv, Q Ma - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
Sample preparation based on extraction techniques plays a crucial role in the entire
analytical process, as it ensures accurate and reliable analysis of analytes by eliminating …

[HTML][HTML] Recent developments in the high-throughput separation of biologically active chiral compounds via high performance liquid chromatography

C De Luca, S Felletti, FA Franchina, D Bozza… - … of Pharmaceutical and …, 2024 - Elsevier
Bioactive compounds, including active pharmaceutical ingredients (APIs), are often chiral
molecules where stereoisomers have different biological and therapeutic activity …

Potency testing of cannabinoids by liquid and supercritical fluid chromatography: Where we are, what we need

S Felletti, C De Luca, A Buratti, D Bozza… - … of Chromatography A, 2021 - Elsevier
Hemp and cannabis industry is undergoing a renewed interest due to legalization of
marijuana (a topic that all countries are discussing, especially in recent years) and the …

Polysaccharide-and β-cyclodextrin-based chiral selectors for enantiomer resolution: Recent developments and applications

CV Bui, T Rosenau, H Hettegger - Molecules, 2021 - mdpi.com
Polysaccharides, oligosaccharides, and their derivatives, particularly of amylose, cellulose,
chitosan, and β-cyclodextrin, are well-known chiral selectors (CSs) of chiral stationary …

Journey to the market: the evolution of biodegradable drug delivery systems

M Zhu, AK Whittaker, FY Han, MT Smith - Applied Sciences, 2022 - mdpi.com
Biodegradable polymers have been used as carriers in drug delivery systems for more than
four decades. Early work used crude natural materials for particle fabrication, whereas more …