Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …

There is abundant evidence that tumor-infiltrating CD8+ T cells contribute positively to
antitumor immunity; however, the role of tumor-infiltrating B cells (TIL-B) and plasma cells …

Objective: We postulated that the ImmunoScore (IS) could markedly improve the prediction
of postsurgical survival and chemotherapeutic benefits in gastric cancer (GC). Summary …

Objective Recent data supports a significant role for immune checkpoint inhibitors in the
treatment of solid tumours. Here, we evaluate gastric and gastro-oesophageal junction …

Gastric cancer (GC) represents the fifth most frequently diagnosed cancer worldwide, with a
poor prognosis in patients with advanced disease despite many improvements in systemic …

Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that
nonsteroidal anti-inflammatory drugs suppress the incidence, growth, and metastasis of …

Background: Tumour-infiltrating lymphocytes (TILs) are often found in tumours, presumably
reflecting an immune response against the tumour. We carried out a systematic review and …

The tumor microenvironment includes a complex network of immune T-cell subpopulations.
In this study, we systematically analyzed the balance between cytotoxic T cells and different …

Background Ipilimumab, a fully human monoclonal antibody that blocks cytotoxic T-
lymphocyte antigen-4, has demonstrated an improvement in overall survival in two phase III …

Background Increasing evidence has indicated an association between immune infiltration
in gastric cancer and clinical outcome. However, reliable prognostic signatures, based on …