The inability of the mammalian central nervous system (CNS) to undergo spontaneous
regeneration has long been regarded as a central tenet of neurobiology. However, although …

How tissues are maintained over a lifetime and repaired following injury are fundamental
questions in biology with a disruption to these processes underlying pathologies such as …

After central nervous system (CNS) demyelination—such as occurs during multiple sclerosis—
there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but …

Little is known of the molecular mechanisms that trigger oligodendrocyte death and
demyelination in many acute central nervous system insults. Since oligodendrocytes …

Demyelination contributes to the dysfunction after traumatic spinal cord injury (SCI). We
explored whether the combination of neurotrophic factors and transplantation of adult rat …

We developed an in situ model to investigate the hypothesis that AMPA/kainate (AMPA/KA)
receptor activation contributes to hypoxic–ischemic white matter injury in the adult brain …

Functional glutamate receptors are expressed on the majority of glial cell types in the
developing and mature brain. Although glutamate receptors on glia are activated by …

Blockade of receptors for the excitatory neurotransmitter glutamate ameliorates neurological
clinical signs in models of the CNS inflammatory demyelinating disease multiple sclerosis …

The myelin sheath, generated by oligodendrocytes in the central nervous system (CNS), is
crucial to neuronal function, enabling rapid propagation of nerve impulses and providing …

Prolonged type 2 diabetes mellitus (T2DM) produces a common complication, peripheral
neuropathy, which is accompanied by nerve fiber disorder, axon atrophy, and …