Circadian Rhythms and Sleep in Drosophila melanogaster
C Dubowy, A Sehgal - Genetics, 2017 - academic.oup.com
The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …
Control of sleep and wakefulness
This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …
Wakefulness promoting systems cause low-voltage, fast activity in the …
A genetically encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice
Dopamine (DA) is a central monoamine neurotransmitter involved in many physiological
and pathological processes. A longstanding yet largely unmet goal is to measure DA …
and pathological processes. A longstanding yet largely unmet goal is to measure DA …
[HTML][HTML] Sleep loss can cause death through accumulation of reactive oxygen species in the gut
A Vaccaro, YK Dor, K Nambara, EA Pollina, C Lin… - Cell, 2020 - cell.com
The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …
VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors
Dopaminergic ventral tegmental area (VTA) neurons are critically involved in a variety of
behaviors that rely on heightened arousal, but whether they directly and causally control the …
behaviors that rely on heightened arousal, but whether they directly and causally control the …
[HTML][HTML] Coordinated and compartmentalized neuromodulation shapes sensory processing in Drosophila
Learned and adaptive behaviors rely on neural circuits that flexibly couple the same sensory
input to alternative output pathways. Here, we show that the Drosophila mushroom body …
input to alternative output pathways. Here, we show that the Drosophila mushroom body …
Chemoconnectomics: mapping chemical transmission in Drosophila
B Deng, Q Li, X Liu, Y Cao, B Li, Y Qian, R Xu, R Mao… - Neuron, 2019 - cell.com
We define the chemoconnectome (CCT) as the entire set of neurotransmitters,
neuromodulators, neuropeptides, and their receptors underlying chemotransmission in an …
neuromodulators, neuropeptides, and their receptors underlying chemotransmission in an …
Exploring phylogeny to find the function of sleep
During sleep, animals do not eat, reproduce or forage. Sleeping animals are vulnerable to
predation. Yet, the persistence of sleep despite evolutionary pressures, and the deleterious …
predation. Yet, the persistence of sleep despite evolutionary pressures, and the deleterious …
A gut-secreted peptide suppresses arousability from sleep
I Titos, A Juginović, A Vaccaro, K Nambara, P Gorelik… - Cell, 2023 - cell.com
Suppressing sensory arousal is critical for sleep, with deeper sleep requiring stronger
sensory suppression. The mechanisms that enable sleeping animals to largely ignore their …
sensory suppression. The mechanisms that enable sleeping animals to largely ignore their …
A subset of dopamine neurons signals reward for odour memory in Drosophila
Animals approach stimuli that predict a pleasant outcome. After the paired presentation of an
odour and a reward, Drosophila melanogaster can develop a conditioned approach towards …
odour and a reward, Drosophila melanogaster can develop a conditioned approach towards …