Boron-containing molecules have been extensively used for the purposes of chemical
sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it …

α-Aminoboronic acids and their derivatives are useful as bioactive agents. Thus far, three
compounds containing an α-aminoboronate motif have been approved by the Food and …

Despite the frequent occurrence of γ-branched amines in bioactive molecules, the direct
catalytic asymmetric synthesis of this structural motif containing a remote stereocenter …

Chiral α-and β-aminoboronic acids exhibit unique biological activities. General methods for
the synthesis of these bioisosteres of amino acids are highly desirable. We report a facile …

A thermodynamic approach to peptide macrocyclization inspired by the cyclization of non-
ribosomal peptide aldehydes is presented. The method provides access to structurally …

For internal alkenes possessing two or more sets of electronically and sterically similar
allylic protons, the site-selectivity for allylic C–H functionalization is fundamentally …

Radical hydroboration reactions have only recently been reported and are still rare. Here we
describe a photoredox radical hydroboration of α, β-unsaturated esters, amides, ketones …

Metal-catalyzed mono-acylmethylation of pyridylcarboranes has been realized using α-
carbonyl sulfoxonium ylides as a coupling partner. The reaction features high efficiency …

Organoboron compounds have a wide-range of applications in synthetic methodologies,
natural products, and bioactive molecule synthesis. The sensitivity of boronic acid toward …

A modular approach to highly functional acyl (MIDA) boronates is described. It involves the
generation of the hitherto unknown radical derived from acetyl (MIDA) boronate and its …