Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Exercise training has been widely recognized as a healthy lifestyle as well as an effective
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …

Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

In 1993, the National Institutes of Health (NIH) enacted the Revitalization Act to establish
guidelines for inclusion of women and minorities in clinical research. In 2016, the NIH …

Growing evidence has demonstrated exercise as an effective way to promote cardiovascular
health and protect against cardiovascular diseases However, the underlying mechanisms of …

Purpose To investigate which type, frequency, duration, intensity, and volume of chronic
exercise might more strongly reduce pro-inflammatory cytokines and enhance anti …

Acute and chronic animal models of exercise are commonly used in research. Acute
exercise testing is used, often in combination with genetic, pharmacological, or other …

Circadian rhythms drive our daily behaviors to coincide with the earth's rotation on an
approximate 24-h cycle. The circadian clock mechanism present in nearly every cell is …

Heart failure represents the end point of a variety of cardiovascular diseases. It is a growing
health burden and a leading cause of death worldwide. To date, limited treatment options …