Genetics in model organisms has progressively broken down walls that previously
separated different disciplines of biology. One example of this holistic evolution is the …

It is from the discovery of leptin and the central nervous system as a regulator of bone
remodeling that the presence of autonomic nerves within the skeleton transitioned from a …

Exosomes, also known as extracellular vesicles, are naturally occurring, biocompatible, and
bioacive nanoparticles ranging from 40 to 150 nm in diameter. Bone-secreted exosomes …

Whether sensory nerve can sense bone density or metabolic activity to control bone
homeostasis is unknown. Here we found prostaglandin E2 (PGE2) secreted by osteoblastic …

Bone formation induced by divalent metal cations has been widely reported; however, the
underlying mechanism is unclear. Here we report that these cations stimulate skeleton …

The sensory nerve was recently identified as being involved in regulation of bone mass
accrual. We previously discovered that prostaglandin E2 (PGE2) secreted by osteoblasts …

The significant biochemical and physiological effects of psychological stress are beginning
to be recognized as exacerbating common diseases, including osteoporosis. This review …

The homeostasis of bone microenvironment is the foundation of bone health and comprises
2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In …

Abstract Coronavirus disease 19 (COVID-19) is currently a global pandemic that affects
patients with other pathologies. Here, we investigated the influence of treatments for …

Fragility fracture is a worldwide problem and a main cause of disability and impaired quality
of life. It is primarily caused by osteoporosis, characterized by impaired bone quantity and or …