Aim and objective Emerging translational evidence suggests that epigenetic alterations
(DNA methylation, miRNA expression, and histone modifications) occur after external stimuli …

Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial
hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV …

The host response to SARS-CoV-2 infection provide insights into both viral pathogenesis
and patient management. The host-encoded microRNA (miRNA) response to SARS-CoV-2 …

Cardiovascular diseases, involving vasculopathy, cardiac dysfunction, or circulatory
disturbance, have become the major cause of death globally and brought heavy social …

Appropriate responses to inflammation are conducive to pathogen elimination and tissue
repair, while uncontrolled inflammatory reactions are likely to result in the damage of tissues …

Background Myocardial ischemia/reperfusion (I/R) injury is a common cause of mortality.
Cardiac miR-146a is emerging as a potent regulator of myocardial function …

Pharmacological PPARγ activation improves many hallmarks of PAH, including dysfunction
of BMPR2-PPARγ axis, PAEC, PASMC, EPC, mitochondria/metabolism, and inflammation …

Once perceived as a disorder treated by vasodilation, pulmonary artery hypertension (PAH)
has emerged as a pulmonary vascular disease with severe endothelial cell dysfunction. In …

Peptides are important components of human nutrition and health, and considered as safe,
nontoxic, and easily absorbed potential drugs. Anti-hypoxia peptides are a kind of peptides …

Background: Myocardial cell death is the hallmark of myocardial infarction. In the process of
myocardial injury, platelets contribute to the pathogenesis by triggering intense inflammatory …