Annual seasonal influenza epidemics of variable severity result in significant morbidity and
mortality in the United States (US) and worldwide. In temperate climate countries, including …

What is known and objective Extracorporeal membrane oxygenation (ECMO) is a life‐saving
system used for critically ill patients with cardiac and/or respiratory failure. The …

The multiple organ dysfunction syndrome (MODS) is characterized by more than one organ
system failing, especially during critical illness. MODS is the leading cause of morbidity and …

Data evaluating pharmacokinetic/pharmacodynamic (PK/PD) aspect in the pediatric
population are scarce especially regarding the pediatric intensive care unit. Dosing of …

Abstract Background and Objective The use of continuous renal replacement therapy
(CRRT) for renal support has increased substantially in critically ill children compared with …

Objectives: This study aimed to identify alterations in pharmacokinetics in children on
extracorporeal membrane oxygenation (ECMO), identify knowledge gaps, and inform future …

Introduction: Pediatric critical illness and associated alterations in organ function can
change drug pharmacokinetics (PK). Extracorporeal membrane oxygenation (ECMO), a life …

Abstract Background and Objectives Patients with severe influenza virus infection, multi-
organ failure and organ replacement therapy may absorb and metabolize neuraminidase …

Acute respiratory infections represent common diseases in childhood and a challenge to
infection control, public heath, and the clinical management of patients and their families …

Oseltamivir is the prodrug of oseltamivir carboxylate, a virustatic inhibitor of influenza A and
B virus replication. Oseltamivir was developed by Gilead Sciences, Foster City, California. It …