Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet
functions. Platelet activation determines a drastic change in redox balance and in platelet …

Circulating blood platelets contain small numbers of fully functional mitochondria.
Accumulating evidence demonstrates that these mitochondria regulate the pro-thrombotic …

Early administration of blood products following severe trauma is pivotal for establishing
hemostasis and achieving successful outcomes. Platelet transfusions, in particular, provide …

Platelet activation plays a key role in cardiovascular diseases. The generation of
mitochondrial reactive oxygen species (ROS) has been described as a critical step required …

Platelets are cellular elements that are physiologically involved in hemostasis, inflammation,
thrombotic events, and various human diseases. There is a link between the activation of …

Mitochondria are key regulators of cellular energy and redox metabolism, also playing a
central role in cell signaling and death pathways. A number of processes occur within …

Platelet activation plays an essential role in the pathogenesis of thrombotic events in
different diseases (eg, cancer, type 2 diabetes, Alzheimer's, and cardiovascular diseases …

Platelets are anucleated cell elements produced by fragmentation of the cytoplasm of
megakaryocytes and have a unique metabolic phenotype compared with circulating …

Introduction Platelet mitochondrial respiratory chain enzymes (that produce energy) are
variably inhibited during human sepsis. Whether these changes occur even during other …

Mitochondrial dysfunction is currently acknowledged as a central pathomechanism of most
common diseases of the 21st century. Recently, the assessment of the bioenergetic profile of …