Infections and glaucoma

K Aldaas, P Challa, DJ Weber, D Fleischman - Survey of Ophthalmology, 2022 - Elsevier
Glaucoma is an intraocular pressure-related ophthalmic disease with multiple causes that
results in an optic neuropathy and vision loss. Intraocular pressure elevation is among its …

Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients

M Zheng, Y Zheng, M Gao, H Ma… - Experimental and …, 2020 - spandidos-publications.com
Expression and clinical value of long non‑coding RNA (lncRNA) MALAT1 and lncRNA
ANRIL in glaucoma patients were investigated. Altogether 86 glaucoma patients who were …

Glucocorticoid-induced cell-derived matrix modulates transforming growth factor β2 signaling in human trabecular meshwork cells

F Yemanyi, J Vranka, VK Raghunathan - Scientific Reports, 2020 - nature.com
Aberrant remodeling of trabecular meshwork (TM) extracellular matrix (ECM) may induce
ocular hypertensive phenotypes in human TM (hTM) cells to cause ocular hypertension, via …

Dexamethasone and glucocorticoid-induced matrix temporally modulate key integrins, caveolins, contractility, and stiffness in human trabecular meshwork cells

F Yemanyi, H Baidouri, AR Burns… - … & visual science, 2020 - iovs.arvojournals.org
Purpose: To determine the temporal effects of dexamethasone (DEX) and glucocorticoid-
induced matrix (GIM) on integrins/integrin adhesomes, caveolins, cytoskeletal-related …

Tissue-engineered models for glaucoma research

R Lu, PA Soden, E Lee - Micromachines, 2020 - mdpi.com
Glaucoma is a group of optic neuropathies characterized by the progressive degeneration of
retinal ganglion cells (RGCs). Patients with glaucoma generally experience elevations in …

[HTML][HTML] Evaluations of aqueous humor protein markers in different types of glaucoma

H Chen, G Zheng, H Chen, L Li, Z Xu, L Xu - Medicine, 2022 - journals.lww.com
Evaluations of aqueous humor protein markers in different ty... : Medicine Evaluations of
aqueous humor protein markers in different types of glaucoma : Medicine Log in or Register Get …

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein

AR Castle, SG Kang… - Proceedings of the …, 2023 - National Acad Sciences
The cellular prion protein (PrPC) converts to alternatively folded pathogenic conformations
(PrPSc) in prion infections and binds neurotoxic oligomers formed by amyloid-β α-synuclein …

Upregulation of local hepcidin contributes to iron accumulation in Alzheimer's disease brains

S Chaudhary, A Ashok, D McDonald… - Journal of …, 2021 - content.iospress.com
Background: Accumulation of iron is a consistent feature of Alzheimer's disease (AD) brains.
The underlying cause, however, remains debatable. Objective: To explore whether local …

[HTML][HTML] Trabecular meshwork cell differentiation in response to collagen and TGFβ-2 spatial interactions.

HC Lamont, AW Wright, K Devrie, KE Okur, M Jones… - Acta Biomaterialia, 2024 - Elsevier
Primary open angle glaucoma (POAG) is currently the most prevalent cause of irreversible
blindness globally. To date, there are few in vitro models that can faithfully recapitulate the …

Local synthesis of hepcidin in the anterior segment of the eye: A novel observation with physiological and pathological implications

A Ashok, S Chaudhary, D McDonald, A Kritikos… - Experimental eye …, 2020 - Elsevier
Purpose The avascular cornea, trabecular meshwork (TM), and lens obtain iron, an
essential biometal, from the aqueous humor (AH). The mechanism by which this exchange …