The conformational plasticity vista of PDZ domains
J Murciano-Calles - Life, 2020 - mdpi.com
The PDZ domain (PSD95-Discs large-ZO1) is a widespread modular domain present in the
living organisms. A prevalent function in the PDZ family is to serve as scaffolding and …
living organisms. A prevalent function in the PDZ family is to serve as scaffolding and …
[HTML][HTML] Genome-wide SNP analysis of Siamese cobra (Naja kaouthia) reveals the molecular basis of transitions between Z and W sex chromosomes and supports …
Elucidation of the process of sex chromosome differentiation is necessary to understand the
dynamics of evolutionary mechanisms in organisms. The W sex chromosome of the …
dynamics of evolutionary mechanisms in organisms. The W sex chromosome of the …
Dynamic community composition unravels allosteric communication in pdz3
The third domain of PSD-95 (PDZ3) is a model for investigating allosteric communication in
protein and ligand interactions. While motifs contributing to its binding specificity have been …
protein and ligand interactions. While motifs contributing to its binding specificity have been …
PDZ/PDZ interaction between PSD‐95 and nNOS neuronal proteins: A thermodynamic analysis of the PSD95‐PDZ2/nNOS‐PDZ interaction
J Murciano‐Calles, A Coello… - Journal of Molecular …, 2020 - Wiley Online Library
Abstract N‐Methyl‐D‐aspartate (NMDA) receptors are key components in synaptic
communication and are highly relevant in central nervous disorders, where they trigger …
communication and are highly relevant in central nervous disorders, where they trigger …
Hypoglycemic Activity of Rice Resistant-Starch Metabolites: A Mechanistic Network Pharmacology and In Vitro Approach
J Ren, J Dai, Y Chen, Z Wang, R Sha, J Mao, Y Mao - Metabolites, 2024 - mdpi.com
Rice (Oryza sativa L.) is one of the primary sources of energy and nutrients needed by the
body, and rice resistant starch (RRS) has been found to have hypoglycemic effects …
body, and rice resistant starch (RRS) has been found to have hypoglycemic effects …
Structure-mechanics statistical learning uncovers mechanical relay in proteins
A protein's adaptive response to its substrates is one of the key questions driving molecular
physics and physical chemistry. This work employs the recently developed structure …
physics and physical chemistry. This work employs the recently developed structure …
Sec8 specifically interacts with the PDZ2 domain of synapse associated protein 102 (SAP102)
K Korbula, I Hammerschmid, J Lesigang… - Frontiers in Cell and …, 2023 - frontiersin.org
The exocyst is an evolutionarily conserved protein complex tethering secretory vesicles
before their docking and fusion with the plasma membrane. The complex also plays …
before their docking and fusion with the plasma membrane. The complex also plays …
N-terminus of the third PDZ domain of PSD-95 orchestrates allosteric communication for selective ligand binding
TF Guclu, N Kocatug, AR Atilgan… - Journal of Chemical …, 2020 - ACS Publications
PDZ domains constitute common models to study single-domain allostery without significant
structural changes. The third PDZ domain of PSD-95 (PDZ3) is known to have selective …
structural changes. The third PDZ domain of PSD-95 (PDZ3) is known to have selective …
Ensemble-Based analysis of the dynamic allostery in the PSD-95 PDZ3 domain in relation to the general variability of PDZ structures
PDZ domains are abundant interaction hubs found in a number of different proteins and they
exhibit characteristic differences in their structure and ligand specificity. Their internal …
exhibit characteristic differences in their structure and ligand specificity. Their internal …
pH-Driven Polymorphic Behaviour of the Third PDZ Domain of PSD95: The Role of Electrostatic Interactions
MC Salinas-García, M Plaza-Garrido, JA Gavira… - Crystals, 2023 - mdpi.com
The PDZ domains are modular domains that recognise short linear C-terminal sequences in
proteins that organise the formation of complex multi-component assemblies. We have …
proteins that organise the formation of complex multi-component assemblies. We have …