Most bacteria are surrounded by a peptidoglycan cell wall that defines their shape and
protects them from osmotic lysis. The expansion and division of this structure therefore plays …

The ability to split one cell into two is fundamental to all life, and many bacteria can
accomplish this feat several times per hour with high accuracy. Most bacteria call on an …

The bacterial division apparatus catalyses the synthesis and remodelling of septal
peptidoglycan (sPG) to build the cell wall layer that fortifies the daughter cell poles …

Bacterial cell division requires recruitment of peptidoglycan (PG) synthases to the division
site by the tubulin homologue, FtsZ. Septal PG synthases promote septum growth. FtsZ …

Bacterial cell division requires septal peptidoglycan (sPG) synthesis by the divisome
complex. Treadmilling of the essential tubulin homologue FtsZ has been implicated in septal …

FtsN plays an essential role in promoting the inward synthesis of septal peptidoglycan (sPG)
by the FtsWI complex during bacterial cell division. How it achieves this role is unclear. Here …

The bacterial divisome is a macromolecular machine composed of more than 30 proteins
that controls cell wall constriction during division. Here, we present a model of the structure …

Bacterial cell wall biosynthesis is the target of many important antibiotics. Its spatiotemporal
organization is closely coordinated with cell division. However, the role of peptidoglycan …

In Escherichia coli, FtsQLB is required to recruit the essential septal peptidoglycan (sPG)
synthase FtsWI to FtsA, which tethers FtsZ filaments to the membrane. The arrival of FtsN …

Decades of research, much of it in Escherichia coli, have yielded a wealth of insight into
bacterial cell division. Here, we provide an overview of the E. coli division machinery with an …