Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Brain injury in the premature infant, a problem of enormous importance, is associated with a
high risk of neurodevelopmental disability. The major type of injury involves cerebral white …

Cerebral white matter injury, characterised by loss of premyelinating oligodendrocytes (pre-
OLs), is the most common form of injury to the preterm brain and is associated with a high …

Since poly-ADP ribose was discovered over 40 years ago, there has been significant
progress in research into the biology of mono-and poly-ADP-ribosylation reactions. During …

Apoptosis-inducing factor (AIF) is a flavin adenine dinucleotide-containing, NADH-
dependent oxidoreductase residing in the mitochondrial intermembrane space whose …

Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and
associated disabilities in children. Cerebral palsy is one of the most costly neurologic …

Background Demyelination and axonal damage are critical processes in the pathogenesis
of multiple sclerosis (MS). Oxidative stress and pro-inflammatory cytokines elicited by …

The translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus has
been implicated in the mechanism of glutamate excitotoxicity in cortical neurons and has …

Reactive microglia in the CNS have been implicated in the pathogenesis of white matter
disorders, such as periventricular leukomalacia and multiple sclerosis. However, the …

The child's brain is more malleable or plastic than that of adults and this accounts for the
ability of children to learn new skills quickly or recovery from brain injuries. Several …