Background The etiology of community-acquired pneumonia (CAP) has evolved since the
beginning of the antibiotic era. Recent guidelines encourage immediate empiric antibiotic …

Immunocompromised patients account for an increasing proportion of the typical intensive
care unit (ICU) case-mix. Because of the increased availability of new drugs for cancer and …

Purpose Severe community-acquired pneumonia (sCAP) is associated with high morbidity
and mortality, and whilst European and non-European guidelines are available for …

Background PCR-based testing has transformed the management of suspected respiratory
viral infections. We aimed to determine whether multiplex bacterial PCR of bronchoalveolar …

Community-acquired pneumonia is not usually considered a high-priority problem by the
public, although it is responsible for substantial mortality, with a third of patients dying within …

Objective To investigate the efficacy, effectiveness and safety of recombinant zoster vaccine
(RZV) and zoster vaccine live (ZVL) in immunocompetent and immunocompromised …

Respiratory virus infection can cause severe illnesses capable of inducing acute respiratory
failure that can progress rapidly to acute respiratory distress syndrome (ARDS). ARDS is …

Background Metagenomic next-generation sequencing (mNGS) is a promising technique for
pathogens diagnosis. However, application of mNGS in immunocompromised adults with …

Pneumonia imposes a significant clinical burden on people with immunocompromising
conditions. Millions of individuals live with compromised immunity because of cytotoxic …

Introduction This study aims to assess the value of metagenomic next-generation
sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) in the diagnosis of …