Short-chain fatty acids (SCFAs) derived from the fermentation of carbohydrates by gut
microbiota play a crucial role in regulating host physiology. Among them, acetate …

Pyroptosis is a novel pro-inflammatory cell programmed death dependent on Gasdermin
(GSMD) family-mediated membrane pore formation and subsequent cell lysis, accompanied …

The gut microbiota regulates chronic inflammation and has been implicated in the
pathogenesis of a broad spectrum of disease including autoimmunity and cancer. Microbial …

Intervertebral disc degeneration (IVDD) can be caused by aging, injury, and genetic factors.
The pathological changes associated with IVDD include the excessive accumulation of …

Apelin/APJ is widely distributed in various tissues in the body and participates in the
regulation of physiological and pathological mechanisms such as autophagy, apoptosis …

Gut microbiota (GM) contributes to the production of immune-regulatory molecules and
cytokines. However, our understanding regarding intricate relationship between …

Many inflammatory disorders, including diabetic kidney disease (DKD), are associated with
pyroptosis, a type of inflammation-regulated cell death. The purpose of this work was to …

Periprosthetic osteolysis (PPO) along with aseptic loosening (AL) caused by wear particles
after artificial joint replacement is the key factor in surgical failure and subsequent revision …

Inflammation, abnormal cholesterol metabolism, and macrophage infiltration are involved in
the destruction of the extracellular matrix of the nucleus pulposus (NP), culminating in …

Cigarette smoke is recognized as a major trigger for individuals with chronic obstructive
pulmonary disease (COPD), leading to an amplified inflammatory response. The onset and …