Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …

Periodontitis (PD) is a common chronic infectious disease. The local inflammatory response
in the host may cause the destruction of supporting periodontal tissue. Macrophages play a …

High mobility group box 1 (HMGB1) is a multifunctional nuclear protein, probably known
best as a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule …

Abstract On May 2017, the World Health Organization recognized sepsis as a global health
priority. Sepsis profoundly perturbs immune homeostasis by initiating a complex response …

Food is our daily companion, performing numerous beneficial functions for our bodies. Many
of them can help to alleviate or prevent ailments and diseases. In this review, an extensive …

Sepsis is a host immune disorder induced by infection. It can lead to multiple organ
dysfunction syndrome (MODS), which has high morbidity and mortality. There has been …

Simple Summary Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease affecting a quarter of the global population and carries the risk of developing …

Most of the leading causes of death, such as cardiovascular diseases, cancer, dementia,
neurodegenerative diseases, and many more, are associated with sterile inflammation …

Despite extensive efforts to develop efficacious therapeutic approaches, the treatment of
skin wounds remains a considerable clinical challenge. Existing remedies cannot sufficiently …

P53 is a transcription factor very often mutated in malignancies. It functions towards the
regulation of important cellular activities, such as cell cycle, senescence and apoptosis …