Enhanced recovery after surgery (ERAS) and its applicability for major spine surgery

TW Wainwright, T Immins, RG Middleton - Best practice & research Clinical …, 2016 - Elsevier
This article examines the relevance of applying the Enhanced Recovery after Surgery
(ERAS) approach to patients undergoing major spinal surgery. The history of ERAS, details …

Safety, efficacy, and cost-effectiveness of tranexamic acid in orthopedic surgery

ZX Lin, SK Woolf - Orthopedics, 2016 - journals.healio.com
Perioperative bleeding and postsurgical hemorrhage are common in invasive surgical
procedures, including orthopedic surgery. Tranexamic acid (TXA) is a pharmacologic agent …

The efficacy of tranexamic acid in total knee arthroplasty: a network meta-analysis

YA Fillingham, DB Ramkumar, DS Jevsevar… - The Journal of …, 2018 - Elsevier
Background A growing body of published research on tranexamic acid (TXA) suggests that it
is effective in reducing blood loss and the risk for transfusion in total knee arthroplasty (TKA) …

Multiple boluses of intravenous tranexamic acid to reduce hidden blood loss after primary total knee arthroplasty without tourniquet: a randomized clinical trial

J Xie, J Ma, H Yao, C Yue, F Pei - The Journal of arthroplasty, 2016 - Elsevier
Background The optimal dosage and timing of tranexamic acid (TXA) in total knee
arthroplasty (TKA) are undetermined. The purpose of this study was to explore the effect of …

Intravenous and topical tranexamic acid alone are superior to tourniquet use for primary total knee arthroplasty: a prospective, randomized controlled trial

ZY Huang, XW Xie, LL Li, Q Huang, J Ma, B Shen… - JBJS, 2017 - journals.lww.com
Background: Tourniquet use during primary total knee arthroplasty is thought to reduce
intraoperative blood loss and improve visibility. Our goal was to investigate whether …

Tranexamic acid in hip and knee arthroplasty

JS Melvin, LS Stryker, RJ Sierra - JAAOS-Journal of the American …, 2015 - journals.lww.com
Perioperative blood loss is a significant concern for patients undergoing total joint
arthroplasty. A growing body of evidence has shown tranexamic acid (TXA) to be effective in …

Prevention of infection in primary THA and TKA

PF Dobson, MR Reed - EFORT open reviews, 2020 - eor.bioscientifica.com
Rates of peri-prosthetic joint infection (PJI) in primary total hip and total knee arthroplasty
range between 0.3% and 1.9%, and up to 10% in revision cases. Significant morbidity is …

Oral vs intravenous vs topical tranexamic acid in primary hip arthroplasty: a prospective, randomized, double-blind, controlled study

ZY Luo, HY Wang, D Wang, K Zhou, FX Pei… - The Journal of …, 2018 - Elsevier
Background Tranexamic acid (TXA) has demonstrated efficacy in reducing blood loss,
reduction in hemoglobin, and blood transfusion requirements in primary total hip …

Oral and intravenous tranexamic acid are equivalent at reducing blood loss following total hip arthroplasty: a randomized controlled trial

E Kayupov, YA Fillingham, K Okroj, DR Plummer… - JBJS, 2017 - journals.lww.com
Background: Tranexamic acid is an antifibrinolytic that has been shown to reduce blood loss
and the need for transfusions when administered intravenously in total hip arthroplasty. Oral …

Comparison of 3 routes of administration of tranexamic acid on primary unilateral total knee arthroplasty: a prospective, randomized, controlled study

X Yuan, B Li, Q Wang, X Zhang - The Journal of arthroplasty, 2017 - Elsevier
Background The mode of administration for tranexamic acid (TXA) to significantly reduce the
decrease in hemoglobin (Hb), number of transfusions, relevant costs, and side effects in …