Most biomedical and pharmaceutical research of the human vascular system aims to
unravel the complex mechanisms that drive disease progression from molecular to organ …

Cardiovascular events are the major cause of morbidity and mortality in Type 2 diabetes
(T2D). This condition is associated with heightened platelet reactivity, contributing to …

Leukocyte adhesion to the endothelium is an early step in the pathogenesis of
atherosclerosis. Effective adhesion requires the binding of leukocytes to their cognate …

Endothelial cells in straight sections of vessels are known to elongate and align in the
direction of flow. This phenotype has been replicated in confluent monolayers of bovine …

At present, little is known about how endothelial cells respond to spatial variations in fluid
shear stress such as those that occur locally during embryonic development, at heart valve …

Atherosclerosis, a chronic inflammatory disorder characterized by endothelial dysfunction
and blood vessel narrowing, is the leading cause of cardiovascular diseases including heart …

Endothelial cells (EC) respond to shear stress to maintain vascular homeostasis, and a
disrupted response is associated with cardiovascular diseases. To understand how different …

Stenosis at arterial bends alters hemodynamics and instigates abnormal disease
progression. This configuration is addressed numerically by exploring pulsatile flow …

Endothelial cell (EC) function is mediated by variable hemodynamic shear stress patterns at
the vascular wall, where complex shear stress profiles directly correlate with blood flow …

Carotid artery diseases, such as atherosclerosis, are a major cause of death in the United
States. Wall shear stresses are known to prompt plaque formation, but there is limited …