LRRK2 and idiopathic Parkinson's disease
The etiology of idiopathic Parkinson's disease (iPD) is multifactorial, and both genetics and
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …
[HTML][HTML] Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
Brain disorders are characterized by the progressive loss of structure and function of the
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …
More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy
M Flores-Leon, TF Outeiro - Acta neuropathologica, 2023 - Springer
The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …
Lipid nanoparticles: promising treatment approach for Parkinson's disease
K Jagaran, M Singh - International Journal of Molecular Sciences, 2022 - mdpi.com
Parkinson's disease (PD), a neurodegenerative disorder, is a life-altering, debilitating
disease exhibiting a severe physical, psychological, and financial burden on patients …
disease exhibiting a severe physical, psychological, and financial burden on patients …
The cell biology of LRRK2 in Parkinson's disease
A Usmani, F Shavarebi, A Hiniker - Molecular and Cellular Biology, 2021 - Am Soc Microbiol
Point mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of
familial Parkinson's disease (PD) and are implicated in a significant proportion of apparently …
familial Parkinson's disease (PD) and are implicated in a significant proportion of apparently …
LRRK2 and the Endolysosomal System in Parkinson's Disease
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant familial
Parkinson's disease (PD), with pathogenic mutations enhancing LRRK2 kinase activity …
Parkinson's disease (PD), with pathogenic mutations enhancing LRRK2 kinase activity …
The development of inhibitors of leucine‐rich repeat kinase 2 (LRRK2) as a therapeutic strategy for Parkinson's disease: the current state of play
S Azeggagh, DC Berwick - British journal of pharmacology, 2022 - Wiley Online Library
Current therapeutic approaches for Parkinson's disease (PD) are based around treatments
that alleviate symptoms but do not slow or prevent disease progression. As such, alternative …
that alleviate symptoms but do not slow or prevent disease progression. As such, alternative …
Ceramide metabolism and Parkinson's disease—therapeutic targets
A Custodia, M Aramburu-Núñez, C Correa-Paz… - Biomolecules, 2021 - mdpi.com
Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to
being the precursor of complex sphingolipids, ceramides can act as second messengers …
being the precursor of complex sphingolipids, ceramides can act as second messengers …
Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications
Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …
[HTML][HTML] Unravelling the role of NFE2L1 in stress responses and related diseases
X Liu, C Xu, W Xiao, N Yan - Redox Biology, 2023 - Elsevier
The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …