The etiology of idiopathic Parkinson's disease (iPD) is multifactorial, and both genetics and
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …

Brain disorders are characterized by the progressive loss of structure and function of the
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …

The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …

Parkinson's disease (PD), a neurodegenerative disorder, is a life-altering, debilitating
disease exhibiting a severe physical, psychological, and financial burden on patients …

Point mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of
familial Parkinson's disease (PD) and are implicated in a significant proportion of apparently …

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant familial
Parkinson's disease (PD), with pathogenic mutations enhancing LRRK2 kinase activity …

Current therapeutic approaches for Parkinson's disease (PD) are based around treatments
that alleviate symptoms but do not slow or prevent disease progression. As such, alternative …

Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to
being the precursor of complex sphingolipids, ceramides can act as second messengers …

Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …

The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …