C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential

E Bokor, S Kun, D Goyard, M Toth, JP Praly… - Chemical …, 2017 - ACS Publications
This Review summarizes close to 500 primary publications and surveys published since
2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het) arenes. A …

The synergistic potential of various teas, herbs and therapeutic drugs in health improvement: a review

F Malongane, LJ McGAW… - … of the Science of Food and …, 2017 - Wiley Online Library
Tea is one of the most widely consumed non‐alcoholic beverages in the world next to water.
It is classified as Camellia sinensis and non‐Camellia sinensis (herbal teas). The common …

Anthocyanins as antidiabetic agents—in vitro and in silico approaches of preventive and therapeutic effects

H Oliveira, A Fernandes, N F. Brás, N Mateus… - Molecules, 2020 - mdpi.com
Many efforts have been made in the past two decades into the search for novel natural and
less-toxic anti-diabetic agents. Some clinical trials have assigned this ability to …

Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition

D Goyard, B Kónya, AS Chajistamatiou… - European Journal of …, 2016 - Elsevier
Glycogen phosphorylase (GP) is a target for the treatment of hyperglycaemia in the context
of type 2 diabetes. This enzyme is responsible for the depolymerization of glycogen into …

Current therapeutic targets and multifaceted physiological impacts of caffeine

X Song, N Kirtipal, S Lee, P Malý… - Phytotherapy …, 2023 - Wiley Online Library
Caffeine, which shares consubstantial structural similarity with purine adenosine, has been
demonstrated as a nonselective adenosine receptor antagonist for eliciting most of the …

Avicularin attenuates lead-induced impairment of hepatic glucose metabolism by inhibiting the ER stress-mediated inflammatory pathway

T Qiu, JX Shi, C Cheng, H Jiang, HN Ruan, J Li, CM Liu - Nutrients, 2022 - mdpi.com
Lead (Pb), an environmental hazard, causes several human diseases. Avicularin (Avi), a
main dietary flavonoid found in several plants and fruits, exhibits potential protective …

Glycogen phosphorylase inhibitors: a patent review (2013-2015)

M Donnier-Maréchal, S Vidal - Expert opinion on therapeutic …, 2016 - Taylor & Francis
Introduction: Control of glycemia is crucial in the treatment of type 2 diabetes complications.
Glycogen phosphorylase (GP) releases glucose from the liver into the blood stream. Design …

Inhibition of glycogen metabolism induces reactive oxygen species-dependent cytotoxicity in anaplastic thyroid cancer in female mice

CD Davidson, JA Tomczak, E Amiel, FE Carr - Endocrinology, 2022 - academic.oup.com
Anaplastic thyroid cancer (ATC) is one of the most lethal solid tumors, yet there are no
effective, long-lasting treatments for ATC patients. Most tumors, including tumors of the …

[HTML][HTML] Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b

E Kyriakis, GA Stravodimos, AL Kantsadi… - FEBS letters, 2015 - Elsevier
We present a study on the binding of gallic acid and its dimer ellagic acid to glycogen
phosphorylase (GP). Ellagic acid is a potent inhibitor with K is of 13.4 and 7.5 μM, in contrast …

Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human …

AL Kantsadi, É Bokor, S Kun, GA Stravodimos… - European Journal of …, 2016 - Elsevier
C-β-d-Glucopyranosyl pyrrole derivatives were prepared in the reactions of pyrrole, 2-, and 3-
aryl-pyrroles with O-peracetylated β-d-glucopyranosyl trichloroacetimidate, while 2-(β-d …