The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …

All women undergo the menopause transition (MT), a neuro-endocrinological process that
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …

Despite widespread sex differences in prevalence and presentation of numerous illnesses
affecting the human brain, there has been little focus on the effect of endocrine ageing. Most …

Sex or gender differences in the risk of Alzheimer's disease and related dementias (ADRD)
differ by world region, suggesting that there are potentially modifiable risk factors for …

Research indicates that after advanced age, the major risk factor for late-onset Alzheimer's
disease is female sex. Out of every three AD patients, two are females with postmenopausal …

The global population is expected to have about 131.5 million people living with Alzheimer's
disease (AD) and other dementias by 2050, posing a severe health crisis. Dementia is a …

Introduction Despite a large preclinical literature demonstrating neuroprotective effects of
estrogen, use of menopausal hormone therapy (HT) for Alzheimer's disease (AD) risk …

Objective To investigate sex differences in late-onset Alzheimer disease (AD) risks by
means of multimodality brain biomarkers (β-amyloid load via 11C-Pittsburgh compound B …

Alzheimer's disease (AD) is a significant neocortical degenerative disorder characterized by
the progressive loss of neurons and secondary alterations in white matter tracts …