Persisters are a small fraction of quiescent bacterial cells that survive lethal antibiotics or
stresses but can regrow under appropriate conditions. Persisters underlie persistent and …

Pyrazinamide (PZA) is still one of the key drugs used in current therapeutic regimens for
tuberculosis (TB). Despite its importance for TB therapy, the mode of action of PZA remains …

Inorganic polyphosphate (polyP), a linear polymer of hundreds of phosphate residues linked
by ATP-like phosphoanhydride bonds, is found in all organisms and performs a wide variety …

The Mycobacterium tuberculosis phosphate-specific transport (Pst) system controls gene
expression in response to phosphate availability by inhibiting the activation of the SenX3 …

PhoU homologs are one of the determinant factors in the regulation of persister formation
and phosphate metabolism in many bacterial species; however, the functions of PhoU …

Bacteria utilize two-component regulatory systems to sense and respond to their
surroundings. Unlike other two-component systems that directly sense through a sensory …

The majority of cellular phosphate (PO4-3; Pi) exists as nucleoside triphosphates, mainly
adenosine triphosphate (ATP), and ribosomal RNA (rRNA). ATP and rRNA are also the …

Inorganic polyphosphate (polyP) is a linear polymer composed of several molecules of
orthophosphate (Pi) linked by energy-rich phosphoanhydride bonds. In Pseudomonas …

Highlights•PhoU is a negative regulator for the Pi-responsive PhoB/PhoR two-component
system.•PhoU controls responses to phosphate and its counterions, such as Mg 2+ and …

Maintenance of cellular phosphate homeostasis is essential for cellular life. The PhoU
protein has emerged as a key regulator of this process in bacteria, and it is suggested to …