Anaphylaxis is a severe, acute, life-threatening multisystem allergic reaction resulting from
the release of a plethora of mediators from mast cells culminating in serious respiratory …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …

Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is
the third most common cause of malignancy-associated mortality. Distant metastases to the …

Cardiovascular disease (CVD) comprises a range of major clinical cardiac and circulatory
diseases, which produce immense health and economic burdens worldwide. Currently …

Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid
(GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by …

Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

Nitric oxide (NO) represents a crucial mediator to regulate cerebral blood flow (CBF) in the
human brain both under basal conditions and in response to somatosensory stimulation. An …

The excitatory neurotransmitter glutamate gates post-synaptic N-methyl-d-aspartate (NMDA)
receptors (NMDARs) to mediate extracellular Ca 2+ entry and stimulate neuronal nitric oxide …

Emerging evidence hints in favor of a life-threatening link between severe acute respiratory
syndrome coronavirus type 2 (SARS-CoV-2) and the cardiovascular system. SARS-CoV-2 …