Because undesirable pharmacokinetics and toxicity are significant reasons for the failure of
drug development in the costly late stage, it has been widely recognized that drug ADMET …

Physiologically based pharmacokinetic modelling is well established in the pharmaceutical
industry and is accepted by regulatory agencies for the prediction of drug–drug interactions …

Minimizing in vitro and in vivo testing in early drug discovery with the use of physiologically
based pharmacokinetic (PBPK) modeling and machine learning (ML) approaches has the …

Malaria is a devastating disease caused by Plasmodium parasites, resulting in
approximately 435000 deaths in 2018. The impact of malaria is compounded by the …

Since their inception in pharmaceutical applications, physiologically-based kinetic (PBK)
models are increasingly being used across a range of sectors, such as safety assessment of …

Introduction: The oral route is the most convenient way of administrating drugs. Therefore,
accurate determination of oral bioavailability is paramount during drug discovery and …

Carbofuran, a widely used carbamate insecticide, is frequently detected in water. In this
study, a high-performance adsorbent (WAB4) for carbofuran was obtained from laboratory …

An important aspect in the development of small molecules as drugs or agrochemicals is
their systemic availability after intravenous and oral administration. The prediction of the …

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in
Toxicology and Risk Assessment presents foundational principles, advanced techniques …

Objectives Miltefosine is the first and only oral medication to be successfully utilized as an
antileishmanial agent. However, the drug is associated with differences in exposure patterns …