An evolutionary perspective on genetic load in small, isolated populations as informed by whole genome resequencing and forward-time simulations

S Mathur, JM Tomeček, LA Tarango-Arámbula… - …, 2023 - academic.oup.com
Small populations are vulnerable to increased genetic load and drift that can lead to
reductions in fitness and adaptive potential. By analyzing 66 individual whole genomes of …

Characterizing and Eliminating the Inbreeding Load

I Nagy, TA Nguyen - Veterinary Sciences, 2023 - mdpi.com
Simple Summary Inbreeding, which is the mating of related animals, is a general
phenomenon in closed populations. Because it is often associated with a decrease in …

Prediction of fitness under different breeding designs in conservation programs

N Pérez‐Pereira, E López‐Cortegano… - Animal …, 2023 - Wiley Online Library
The expected change in fitness under inbreeding due to deleterious recessive alleles
depends on the amount of inbreeding load harbored by a population, that is, the load of …

Sonification of genomic data to represent genetic load in zoo populations

EJ Martin, SA Speak, L Urban, HE Morales… - Zoo …, 2024 - Wiley Online Library
Maintaining a diverse gene pool is important in the captive management of zoo populations,
especially in endangered species such as the pink pigeon (Nesoenas mayeri). However …

What can genome sequence data reveal about population viability?

M Kardos, LF Keller, WC Funk - Molecular Ecology, 2024 - Wiley Online Library
Biologists have long sought to understand the impacts of deleterious genetic variation on
fitness and population viability. However, our understanding of these effects in the wild is …

Fitness consequences and ancestry loss in the Apennine brown bear after a simulated genetic rescue intervention

F Maroso, G Padovani, VH Muñoz Mora… - Conservation …, 2023 - Wiley Online Library
Reduction in population size, with its predicted effects on population fitness, is the most
alarming anthropogenic impact on endangered species. By introducing compatible …

Pedigree analysis in the mhorr gazelle (Nanger dama mhorr): Genetic variability evolution of the captive population

S Domínguez, I Cervantes, JP Gutiérrez… - Ecology and …, 2024 - Wiley Online Library
Breeding programs have an essential role in the recovery of threatened populations through
optimal genetic management and mating strategies. The dama gazelle (Nanger dama) is a …

Purging of highly deleterious alleles through an extreme bottleneck

OP Stuart, R Cleave, K Pearce, MJL Magrath… - bioRxiv, 2024 - biorxiv.org
Transitions to captivity often produce population bottlenecks. On one hand, bottlenecks
increase inbreeding and decrease effective population size, thus increasing extinction risk …

Insights from the rescue and breeding management of Cuvier's gazelle (Gazella cuvieri) through whole‐genome sequencing

M Alvarez‐Estape, C Fontsere… - Evolutionary …, 2022 - Wiley Online Library
Captive breeding programmes represent the most intensive type of ex situ population
management for threatened species. One example is the Cuvier's gazelle programme that …

The burden of anthropogenic changes and mutation load in a critically endangered harrier from the Reunion biodiversity hotspot, Circus maillardi

Y Bourgeois, BH Warren, S Augiron - Molecular Ecology, 2024 - Wiley Online Library
Anthropogenic impact is causing the decline of a large proportion of species worldwide and
reduces their genetic diversity. Island species typically have smaller ranges than continental …