During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

The hallmarks of cancer are characterized by functional capabilities that allow cancer cells
to survive, proliferate and disseminate during the multistep tumorigenesis. Cancer being a …

Exomeres are a recently discovered type of extracellular nanoparticle with no known
biological function. Herein, we describe a simple ultracentrifugation-based method for …

Glycosylation of proteins is one of the most important PTMs, with more than half of all human
proteins estimated to be glycosylated. It is widely known that aberrant glycosylation has …

Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

Cell surface glycosylation is dynamic and often changes in response to cellular
differentiation under physiological or pathophysiological conditions. Altered glycosylation on …

Aberrant glycosylation is a universal feature of cancer cells and there is now overwhelming
evidence that glycans can modulate pathways intrinsic to tumour cell biology. Glycans are …

We conducted a genome-wide association study (GWAS) and a genome-wide gene-
environment interaction analysis of esophageal squamous-cell carcinoma (ESCC) in 2,031 …

Colon adenocarcinomas are known to express elevated levels of α2-6 sialylation and
increased activity of ST6Gal-I, the Golgi glycosyltransferase that creates α2-6 linkages …

Background One of the new roles for enzymes in personalized medicine builds on a rational
approach to cancer biomarker discovery using enzyme-associated aberrant glycosylation. A …