Higher-order chromatin structure: bridging physics and biology
G Fudenberg, LA Mirny - Current opinion in genetics & development, 2012 - Elsevier
Advances in microscopy and genomic techniques have provided new insight into spatial
chromatin organization inside of the nucleus. In particular, chromosome conformation …
chromatin organization inside of the nucleus. In particular, chromosome conformation …
The scales, mechanisms, and dynamics of the genome architecture
L Lizana, YB Schwartz - Science Advances, 2024 - science.org
Even when split into several chromosomes, DNA molecules that make up our genome are
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …
Complexity of chromatin folding is captured by the strings and binders switch model
M Barbieri, M Chotalia, J Fraser… - Proceedings of the …, 2012 - National Acad Sciences
Chromatin has a complex spatial organization in the cell nucleus that serves vital functional
purposes. A variety of chromatin folding conformations has been detected by single-cell …
purposes. A variety of chromatin folding conformations has been detected by single-cell …
[HTML][HTML] The fractal globule as a model of chromatin architecture in the cell
LA Mirny - Chromosome research, 2011 - Springer
The fractal globule is a compact polymer state that emerges during polymer condensation as
a result of topological constraints which prevent one region of the chain from passing across …
a result of topological constraints which prevent one region of the chain from passing across …
[HTML][HTML] Structure and dynamics of interphase chromosomes
A Rosa, R Everaers - PLoS computational biology, 2008 - journals.plos.org
During interphase chromosomes decondense, but fluorescent in situ hybridization
experiments reveal the existence of distinct territories occupied by individual chromosomes …
experiments reveal the existence of distinct territories occupied by individual chromosomes …
[HTML][HTML] The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions
The immunoglobulin heavy-chain (Igh) locus is organized into distinct regions that contain
multiple variable (VH), diversity (DH), joining (JH) and constant (CH) coding elements. How …
multiple variable (VH), diversity (DH), joining (JH) and constant (CH) coding elements. How …
Spatially confined folding of chromatin in the interphase nucleus
J Mateos-Langerak, M Bohn… - Proceedings of the …, 2009 - National Acad Sciences
Genome function in higher eukaryotes involves major changes in the spatial organization of
the chromatin fiber. Nevertheless, our understanding of chromatin folding is remarkably …
the chromatin fiber. Nevertheless, our understanding of chromatin folding is remarkably …
[HTML][HTML] Diffusion-driven looping provides a consistent framework for chromatin organization
M Bohn, DW Heermann - PloS one, 2010 - journals.plos.org
Chromatin folding inside the interphase nucleus of eukaryotic cells is done on multiple
scales of length and time. Despite recent progress in understanding the folding motifs of …
scales of length and time. Despite recent progress in understanding the folding motifs of …
Models of chromosome structure
M Nicodemi, A Pombo - Current opinion in cell biology, 2014 - Elsevier
Understanding the mechanisms that control chromosome folding in the nucleus of
eukaryotes and their contribution to gene regulation is a key open issue in molecular …
eukaryotes and their contribution to gene regulation is a key open issue in molecular …
Crumpled polymer with loops recapitulates key features of chromosome organization
Chromosomes are exceedingly long topologically constrained polymers compacted in a cell
nucleus. We recently suggested that chromosomes are organized into loops by an active …
nucleus. We recently suggested that chromosomes are organized into loops by an active …