Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
The signal pathways and treatment of cytokine storm in COVID-19
L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …
and is more devastating than any other previous infectious disease. It has affected a …
The metabolic nature of inflammatory bowel diseases
TE Adolph, M Meyer, J Schwärzler, L Mayr… - Nature Reviews …, 2022 - nature.com
Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …
Current and future status of JAK inhibitors
DP McLornan, JE Pope, J Gotlib, CN Harrison - The lancet, 2021 - thelancet.com
An enhanced understanding of the importance of Janus kinase (JAK) and signal transducer
and activator of transcription (STAT) signalling in multiple disease states has led to an …
and activator of transcription (STAT) signalling in multiple disease states has led to an …
Regulatory role of short-chain fatty acids in inflammatory bowel disease
Z Zhang, H Zhang, T Chen, L Shi, D Wang… - Cell Communication and …, 2022 - Springer
Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory disorders of
the gastrointestinal tract. Accumulating evidence shows that the development of IBD is …
the gastrointestinal tract. Accumulating evidence shows that the development of IBD is …
Recent advances in the treatment of IBD: Targets, mechanisms and related therapies
J Liu, B Di, L Xu - Cytokine & Growth Factor Reviews, 2023 - Elsevier
Inflammatory bowel disease (IBD), as a representative inflammatory disease, currently has
multiple effective treatment options available and new therapeutic strategies are being …
multiple effective treatment options available and new therapeutic strategies are being …
[HTML][HTML] Guselkumab for the treatment of Crohn's disease: induction results from the phase 2 GALAXI-1 study
WJ Sandborn, GR D'Haens, W Reinisch, J Panés… - Gastroenterology, 2022 - Elsevier
Background & Aims Guselkumab, a selective p19 interleukin-23 antagonist, is approved for
the treatment of plaque psoriasis and psoriatic arthritis. This study evaluated the efficacy and …
the treatment of plaque psoriasis and psoriatic arthritis. This study evaluated the efficacy and …
Interaction between lipopolysaccharide and gut microbiota in inflammatory bowel diseases
Lipopolysaccharides (LPSs) are bacterial surface glycolipids, produced by Gram-negative
bacteria. LPS is known to determine acute inflammatory reactions, particularly in the context …
bacteria. LPS is known to determine acute inflammatory reactions, particularly in the context …
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …
COVID-19 and immunomodulation in IBD
MF Neurath - Gut, 2020 - gut.bmj.com
The current coronavirus pandemic is an ongoing global health crisis due to COVID-19,
caused by severe acute respiratory syndrome coronavirus 2. Although COVID-19 leads to …
caused by severe acute respiratory syndrome coronavirus 2. Although COVID-19 leads to …