[HTML][HTML] NRF2, a transcription factor for stress response and beyond

F He, X Ru, T Wen - International journal of molecular sciences, 2020 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

[HTML][HTML] NRF2 and the Hallmarks of Cancer

MR de la Vega, E Chapman, DD Zhang - Cancer cell, 2018 - cell.com
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Role of Nrf2 in aging, Alzheimer's and other neurodegenerative diseases

M George, M Tharakan, J Culberson, AP Reddy… - Ageing Research …, 2022 - Elsevier
Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Redox regulation by NRF2 in aging and disease

CJ Schmidlin, MB Dodson, L Madhavan… - Free Radical Biology and …, 2019 - Elsevier
NRF2, a transcription factor that has been deemed the master regulator of cellular redox
homeostasis, declines with age. NRF2 transcriptionally upregulates genes that combat …

Modulating NRF2 in disease: timing is everything

M Dodson, MR de la Vega… - Annual review of …, 2019 - annualreviews.org
The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central
regulator of redox, metabolic, and protein homeostasis that intersects with many other …

[HTML][HTML] Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat …

X Li, X Xie, W Lian, R Shi, S Han, H Zhang… - … & molecular medicine, 2018 - nature.com
Diabetic foot ulcers (DFU) increase the risks of infection and amputation in patients with
diabetes mellitus (DM). The impaired function and senescence of endothelial progenitor …

Potential strategies overcoming the temozolomide resistance for glioblastoma

S Jiapaer, T Furuta, S Tanaka, T Kitabayashi… - Neurologia medico …, 2018 - jstage.jst.go.jp
Glioblastoma (GBM) is a highly malignant type of primary brain tumor with a high mortality
rate. Although the current standard therapy consists of surgery followed by radiation and …

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …

LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

[HTML][HTML] Proteostasis, oxidative stress and aging

I Korovila, M Hugo, JP Castro, D Weber, A Höhn… - Redox biology, 2017 - Elsevier
The production of reactive species is an inevitable by-product of metabolism and thus, life
itself. Since reactive species are able to damage cellular structures, especially proteins, as …

[HTML][HTML] Nrf2: redox and metabolic regulator of stem cell state and function

X Dai, X Yan, KA Wintergerst, L Cai, BB Keller… - Trends in Molecular …, 2020 - cell.com
Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic
cells and functions to induce a broad range of cellular defenses against exogenous and …